Characterization of isoquinoline alkaloids from Neolitsea sericea var. aurata by HPLC-SPE-NMR

被引：53

作者：

Lee, Shoei-Sheng ^{[1
]}

Lai, Yi-Chun

Chen, Chien-Kuang

Tseng, Li-Hong

Wang, Chen-Yu

机构：

[1] Natl Taiwan Univ, Coll Med, Sch Pharm, Taipei 100, Taiwan

[2] Bruker Biospin GmbH, D-76287 Rheinstetten, Germany

来源：

JOURNAL OF NATURAL PRODUCTS | 2007年 / 70卷 / 04期

关键词：

D O I：

10.1021/np060636p

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Application of the HPLC-SPE-NMR technique to identify the alkaloids in an EtOH extract of the leaves of Neolitsea sericea var. aurata led to the characterization of 14 alkaloids while consuming plant material equivalent to 1.1 g. Of these, seven are N-oxides, four of which are new, namely, 9S,17S-pallidine N-alpha-oxide (6), 1S,2S-reticuline N-alpha-oxide (8), 6R,6aS-boldine N-beta-oxide (9), and 6S,6aS-N-methyllaurotetanine N-alpha-oxide (13). Their structures were also confirmed by partial synthesis.

引用

页码：637 / 642

页数：6

共 17 条

[1] CONSTITUENTS OF PACHYGONE-OVATA AND PHARMACOLOGICAL ACTION OF ITS MAJOR LEAF ALKALOID [J].

DASGUPTA, S ;

RAY, AB ;

BHATTACHARYA, SK ;

BOSE, R .

JOURNAL OF NATURAL PRODUCTS, 1979, 42 (04) :399-406

[2] Two novel proaporphine-tryptamine dimers from Roemeria hybrida [J].

Günes, HS ;

Gözler, B .

FITOTERAPIA, 2001, 72 (08) :875-886

[3]

ISRAILOV IA, 1977, CHEM NAT COMPD, P702

[4] Hyphenated NMR methods in natural products research, Part 2: HPLC-SPE-NMR and other new trends in NMR hyphenation [J].

Jaroszewski, JW .

PLANTA MEDICA, 2005, 71 (09) :795-802

[5]

KUO Y-H, 1989, Kaohsiung Journal of Medical Sciences, V5, P360

[6]

Kuo YH, 1992, J CHIN MED, V3, P19

[7]

Lee Shoe-Sheng, 1995, Chinese Pharmaceutical Journal, V47, P69

[8] ISOQUINOLINE ALKALOIDS FROM NEOLITSEA-KONISHII [J].

LEE, SS ;

YANG, HC .

JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 1992, 39 (02) :189-194

[9] QUATERNARY ALKALOIDS FROM LITSEA-CUBEBA AND CRYPTOCARYA-KONISHII [J].

LEE, SS ;

LIN, YJ ;

CHEN, CK ;

LIU, KCS ;

CHEN, CH .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (11) :1971-1976

[10]

Liao J.C., 1996, FLORA TAIWAN, V2, P495

← 1 2 →