A Pair of Dopamine Neurons Target the D1-Like Dopamine Receptor DopR in the Central Complex to Promote Ethanol-Stimulated Locomotion in Drosophila

被引：141

作者：

Kong, Eric C. ^{[1
]}

Woo, Katherine ^{[2
]}

Li, Haiyan ^{[3
]}

Lebestky, Tim ^{[4
]}

Mayer, Nasima ^{[5
]}

Sniffen, Melissa R. ^{[2
]}

Heberlein, Ulrike ^{[1
,2
]}

Bainton, Roland J. ^{[5
]}

Hirsh, Jay ^{[3
]}

Wolf, Fred W. ^{[1
]}

机构：

[1] Ernest Gallo Clin & Res Ctr, Emeryville, CA USA

[2] Univ Calif San Francisco, Dept Anat, San Francisco, CA 94143 USA

[3] Univ Virginia, Dept Biol, Charlottesville, VA USA

[4] CALTECH, Div Biol, Pasadena, CA 91125 USA

[5] Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA 94143 USA

来源：

PLOS ONE | 2010年 / 5卷 / 03期

基金：

美国国家卫生研究院;

关键词：

CENTRAL-NERVOUS-SYSTEM; GENE-EXPRESSION; MUSHROOM BODIES; SYNAPTIC-TRANSMISSION; DIFFERENT FORMS; ELLIPSOID BODY; MOTOR-ACTIVITY; TERM-MEMORY; COCAINE; LOCALIZATION;

D O I：

10.1371/journal.pone.0009954

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dopamine is a mediator of the stimulant properties of drugs of abuse, including ethanol, in mammals and in the fruit fly Drosophila. The neural substrates for the stimulant actions of ethanol in flies are not known. We show that a subset of dopamine neurons and their targets, through the action of the D1-like dopamine receptor DopR, promote locomotor activation in response to acute ethanol exposure. A bilateral pair of dopaminergic neurons in the fly brain mediates the enhanced locomotor activity induced by ethanol exposure, and promotes locomotion when directly activated. These neurons project to the central complex ellipsoid body, a structure implicated in regulating motor behaviors. Ellipsoid body neurons are required for ethanol-induced locomotor activity and they express DopR. Elimination of DopR blunts the locomotor activating effects of ethanol, and this behavior can be restored by selective expression of DopR in the ellipsoid body. These data tie the activity of defined dopamine neurons to D1-like DopR-expressing neurons to form a neural circuit that governs acute responding to ethanol.

引用

页数：15

共 78 条

[21] Ventral tegmental area neurons in. learned appetitive behavior and positive reinforcement [J].