Hydrogels as extracellular matrices for skeletal tissue engineering: state-of-the-art and novel application in organ printing

被引:314
作者
Fedorovich, Natalja E.
Alblas, Jacqueline
de Wijn, Joost R.
Hennink, Wim E.
Verbout, Ab J.
Dhert, Wouter J. A.
机构
[1] Univ Utrecht, Med Ctr, Dept Orthoped, NL-3508 GA Utrecht, Netherlands
[2] Univ Twente, Inst BioMed Technol, NL-7500 AE Enschede, Netherlands
[3] Univ Utrecht, Inst Pharmaceut Sci, Dept Pharmaceut, Utrecht, Netherlands
来源
TISSUE ENGINEERING | 2007年 / 13卷 / 08期
关键词
D O I
10.1089/ten.2006.0175
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Organ printing, a novel approach in tissue engineering, applies layered computer- driven deposition of cells and gels to create complex 3- dimensional cell- laden structures. It shows great promise in regenerative medicine, because it may help to solve the problem of limited donor grafts for tissue and organ repair. The technique enables anatomical cell arrangement using incorporation of cells and growth factors at predefined locations in the printed hydrogel scaffolds. This way, 3- dimensional biological structures, such as blood vessels, are already constructed. Organ printing is developing fast, and there are exciting new possibilities in this area. Hydrogels are highly hydrated polymer networks used as scaffolding materials in organ printing. These hydrogel matrices are natural or synthetic polymers that provide a supportive environment for cells to attach to and proliferate and differentiate in. Successful cell embedding requires hydrogels that are complemented with biomimetic and extracellular matrix components, to provide biological cues to elicit specific cellular responses and direct new tissue formation. This review surveys the use of hydrogels in organ printing and provides an evaluation of the recent advances in the development of hydrogels that are promising for use in skeletal regenerative medicine. Special emphasis is put on survival, proliferation and differentiation of skeletal connective tissue cells inside various hydrogel matrices.
引用
收藏
页码:1905 / 1925
页数:21
相关论文
共 259 条
[51]   Chitosan: A versatile biopolymer for orthopaedic tissue-engineering [J].
Di Martino, A ;
Sittinger, M ;
Risbud, MV .
BIOMATERIALS, 2005, 26 (30) :5983-5990
[52]   Marrow stromal cells embedded in alginate for repair of osteochondral defects [J].
Diduch, DR ;
Jordan, LCM ;
Mierisch, CM ;
Balian, G .
ARTHROSCOPY, 2000, 16 (06) :571-577
[53]   Cellular response to transforming growth factor-beta 1 and basic fibroblast growth factor depends on release kinetics and extracellular matrix interactions [J].
Dinbergs, ID ;
Brown, L ;
Edelman, ER .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (47) :29822-29829
[54]   Behavior of human articular chondrocytes derived from nonarthritic and osteoarthritic cartilage in a collagen matrix [J].
Dorotka, R ;
Bindreiter, U ;
Vavken, P ;
Nehrer, S .
TISSUE ENGINEERING, 2005, 11 (5-6) :877-886
[55]   Hydrogels for tissue engineering: scaffold design variables and applications [J].
Drury, JL ;
Mooney, DJ .
BIOMATERIALS, 2003, 24 (24) :4337-4351
[56]  
Eid K, 2001, J BIOMED MATER RES, V57, P224, DOI 10.1002/1097-4636(200111)57:2<224::AID-JBM1162>3.0.CO
[57]  
2-F
[58]  
Elisseeff J, 2000, J BIOMED MATER RES, V51, P164, DOI 10.1002/(SICI)1097-4636(200008)51:2<164::AID-JBM4>3.0.CO
[59]  
2-W
[60]   The role of biomaterials in stem cell differentiation: Applications in the musculoskeletal system [J].
Elisseeff, J. ;
Ferran, A. ;
Hwang, S. ;
Varghese, S. ;
Zhang, Z. .
STEM CELLS AND DEVELOPMENT, 2006, 15 (03) :295-303