Ca2+ regulation and gene expression in normal brain aging

被引：170

作者：

Toescu, EC ^{[1
]}

Verkhratsky, A

Landfield, PW

机构：

[1] Univ Birmingham, Dept Physiol, Div Med Sci, Birmingham B15 2TT, W Midlands, England

[2] Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England

[3] Univ Kentucky, Coll Med, Dept Mol & Biomed Pharmacol, Lexington, KY 40536 USA

来源：

TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 10期

关键词：

D O I：

10.1016/j.tins.2004.07.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca2+ influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca2+ regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.

引用

页码：614 / 620

页数：7

共 69 条

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