Insertion site of the locus of enterocyte effacement in enteropathogenic and enterohemorrhagic Escherichia coli differs in relation to the clonal phylogeny of the strains

被引：75

作者：

Wieler, LH

McDaniel, TK

Whittam, TS

Kaper, JB

机构：

[1] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA

[2] Univ Giessen, Inst Hyg & Infekt Krankheiten Tiere, D-35392 Giessen, Germany

[3] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[4] Penn State Univ, Inst Mol Evolut Genet, University Pk, PA 16802 USA

来源：

FEMS MICROBIOLOGY LETTERS | 1997年 / 156卷 / 01期

关键词：

pathogenicity island; locus of enterocyte effacement; enteropathogenic Escherichia coli; enterohemorrhagic Escherichia coli; evolution;

D O I：

10.1016/S0378-1097(97)00403-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The locus of enterocyte effacement pathogenicity island confers the attaching and effacing histopathology on epithelial cells infected with enteropathogenic and enterohemorrhagic Escherichia coli. We investigated the site of insertion of the locus of enterocyte effacement in E. coli strains in relation to their evolution based on conservation of housekeeping proteins in these strains. The results indicate that the insertion site of the locus of enterocyte effacement varies according to the evolutionary lineage, suggesting that it has inserted at multiple times and sites during the evolution of these pathogens.

引用

页码：49 / 53

页数：5

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