Puerarin Ameliorates D-Galactose Induced Enhanced Hippocampal Neurogenesis and Tau Hyperphosphorylation in Rat Brain

被引：52

作者：

Hong, Xiao-Ping ^{[1
]}

Chen, Tao ^{[1
]}

Yin, Ni-Na ^{[1
]}

Han, Yong-Ming ^{[1
]}

Yuan, Fang ^{[2
]}

Duan, Yan-Jun ^{[1
]}

Shen, Feng ^{[3
]}

Zhang, Yan-Hong ^{[1
]}

Chen, Ze-Bin ^{[1
]}

机构：

[1] Hubei Univ Chinese Med, Coll Basic Med, Dept Anat & Histol, Wuhan 430065, Peoples R China

[2] Hubei Univ Chinese Med, Cent Lab, Coll Basic Med, Wuhan, Peoples R China

[3] Hubei Univ Chinese Med, Coll Acupuncture & Orthoped, Dept Acupuncture & Moxibust, Wuhan, Peoples R China

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2016年 / 51卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Alzheimer's disease; glycogen synthase kinase; hippocampus; neurogenesis; Puerarin; spatial memory; tau hyperphosphorylation; SYNTHASE KINASE-3-BETA; DEVELOPMENTAL-CHANGES; MEMORY FORMATION; MOUSE MODEL; PROTEIN-TAU; PHOSPHORYLATION; EXPRESSION; MICE; LOCALIZATION; INHIBITION;

D O I：

10.3233/JAD-150566

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Enhanced neurogenesis has been reported in the hippocampus of patients with Alzheimer's disease (AD), the most common neurodegenerative disorder characterized with amyloid-beta (A beta) aggregation, tau hyperphosphorylation, and progressive neuronal loss. Previously we reported that tau phosphorylation played an essential role in adult hippocampal neurogenesis, and activation of glycogen synthase kinase (GSK-3), a crucial tau kinase, could induce increased hippocampal neurogenesis. In the present study, we found that treatment of D-galactose rats with Puerarin could significantly improve behavioral performance and ameliorate the enhanced neurogenesis and microtubule-associated protein tau hyperphosphorylation in the hippocampus of D-galactose rat brains. FGF-2/GSK-3 signaling pathway might be involved in the effects of Puerarin on hippocampal neurogenesis and tau hyperphosphorylation. Our finding provides primary in vivo evidence that Puerarin can attenuate AD-like enhanced hippocampal neurogenesis and tau hyperphosphorylation. Our finding also suggests Puerarin can be served as a treatment for age-related neurodegenerative disorders, such as AD.

引用

页码：605 / 617

页数：13

共 57 条

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