Cytogenetic and interphase cytogenetic analyses reveal chromosome instability but no clonal trisomy 8 in Dupuytren contracture

被引：18

作者：

Casalone, R ^{[1
]}

Mazzola, D ^{[1
]}

Meroni, E ^{[1
]}

Righi, R ^{[1
]}

Minelli, E ^{[1
]}

Granata, P ^{[1
]}

Panattoni, A ^{[1
]}

Viotto, AM ^{[1
]}

Modesti, M ^{[1
]}

Pilato, G ^{[1
]}

机构：

[1] UNIV PAVIA,IST ORTOPED & TRAUMATOL,VARESE,ITALY

来源：

CANCER GENETICS AND CYTOGENETICS | 1997年 / 99卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(96)00430-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The results of cytogenetic and FISH analysis performed in 26 cases of Dupuytren contracture are reported. Clonal or sporadic chromosome changes were found in 18 cases (69%). Clonal changes consisted of: +2, +16, -10, -Y, add(1)(p23), del(2)(q21), t(3;16)(p21;q24), add(3)(p24), del(18)(q21), t(Y;14)(p12;q24), +mar. The results differ from those obtained in normal palmar fascia used as control, in which -Y and +Y were the only clonal changes found in 2 of 11 analyzed cases (18%). No clonal trisomy 8 was found. FISH analysis performed in 11 cases (centromeric probe specific for chromosome 8) failed to show the presence of a cell population with +8. Clonal and sporadic structural changes were different from case to case and no clustering breakpoint was observed. The significance of the chromosome instability leading to clonal and sporadic chromosome changes not specific to Dupuytren contracture are discussed. (C) Elsevier Science Inc., 1997.

引用

页码：73 / 76

页数：4

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