CD36 and atherosclerosis

被引：105

作者：

Silverstein, RL ^{[1
]}

Febbraio, M ^{[1
]}

机构：

[1] Cornell Univ, Weill Med Coll, Dept Med, Div Hematol & Med Oncol, New York, NY 10021 USA

来源：

CURRENT OPINION IN LIPIDOLOGY | 2000年 / 11卷 / 05期

关键词：

D O I：

10.1097/00041433-200010000-00006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

CD36 has been associated with diverse normal and pathologic processes, These include scavenger receptor functions (uptake of apoptotic cells and modified lipid), lipid metabolism and fatty acid transport, adhesion, angiogenesis, modulation of inflammation, transforming growth factor-beta activation, atherosclerosis, diabetes and cardiomyopathy. Although CD36 was identified more than 25 years ago, it is only with the advent of recent genetic technology that in-vivo evidence has emerged for its physiologic and pathologic relevance, As these in-vivo studies are expanded, we will gain further insight into the mechanism(s) by which CD36 transmits a cellular signal, and this will allow the design of specific therapeutics that impact on a particular function of CD36. Curr Opin Lipidol 11:483-491. (C) 2000 Lippincott Williams & Wilkins.

引用

页码：483 / 491

页数：9

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