Comparison of fluorotyrosines and methionine uptake in F98 rat gliomas

被引：124

作者：

Langen, KJ ^{[1
]}

Jarosch, M

Mühlensiepen, H

Hamacher, K

Bröer, S

Jansen, P

Zilles, K

Coenen, HH

机构：

[1] Forschungszentrum Julich, Res Ctr, Inst Med, Julich, Germany

[2] Forschungszentrum Julich, Res Ctr, Inst Nucl Chem, Julich, Germany

[3] Australian Natl Univ, Fac Sci, Sch Biochem & Mol Biol, Canberra, ACT, Australia

[4] Forschungszentrum Julich, Res Ctr, Cent Inst Appl Math, Julich, Germany

来源：

NUCLEAR MEDICINE AND BIOLOGY | 2003年 / 30卷 / 05期

关键词：

O-(2-[F-18]fluoroethyl)-L-tyrosine (FET); 2-[F-18]fluoro-L-tyrosine (FTyr); H-3]-Methyl-L-methio nine (MET); radiolabelled amino acids; F98-glioma cells; PET;

D O I：

10.1016/S0969-8051(03)00023-4

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The transport mechanisms of O-(2-[F-18]fluoroethyl)-L-tyrosine (FET) and 2-[F-18]fluoro-L-tyrosine (FTyr) were compared to those of [H-3]-Methyl-L-methionine (MET) in F98 rat glioma cells in vitro and by tumor imaging by ex vivo dual tracer autoradiography in F98 rat gliomas. Both, FET and FTyr exhibited similar transport characteristics in F98 glioma cells compared to MET, i.e. mainly a sodium dependent transport similar to system B-0,B-+ and sodium independent transport via system L. Radioactivity of FET in the acid precipitable fraction was <1% after 120 min incubation time while FTyr and MET exhibited a 15-18% incorporation into proteins. Comparison of FET and FTyr with MET uptake in F98 rat gliomas demonstrated a significant correlation of tumor to brain ratios and a similar intratumoral tracer distribution pattern. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：501 / 508

页数：8

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