A pilot study on the effects of sodium oxybate on sleep architecture and daytime alertness in narcolepsy

被引:119
作者
Mamelak, M
Black, J
Montplaisir, J
Ristanovic, R
机构
[1] Univ Toronto, Dept Psychiat, Toronto, ON, Canada
[2] Stanford Univ, Stanford Sleep Disorders Clin, Stanford, CA 94305 USA
[3] Hop Sacre Coeur, Ctr Etud Sommeil, Montreal, PQ H4J 1C5, Canada
[4] Sleep Disorders Ctr, Dept Neurol, Evanston, IL USA
关键词
sodium oxybate; narcolepsy; cataplexy; sleep architecture; gamma-hydroxybutyrate;
D O I
10.1093/sleep/27.7.1327
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Study Objectives: To measure the effect of nocturnal sodium oxybate administration on sleep architecture in patients with narcolepsy. Design: Open-label study. Setting: Four accredited sleep clinics. Participants: 25 adult patients with narcolepsy-cataplexy. Interventions: Patients were weaned from previously used anticataplectic medications and administered increasing nightly doses of sodium oxybate over a 10-week period: 4.5 g for 4 weeks, 6 g for 2 weeks, 7.5 g for 2 weeks, and 9 g for 2 weeks. The effect of sodium oxybate was measured using nocturnal polysomnograms, the Epworth Sleepiness Scale, the Maintenance of Wakefulness Test, and a narcolepsy symptoms questionnaire. Results: The nightly administration of sodium oxybate produced dose-related increases in slow-wave sleep and delta power, rapid eye movement sleep increased initially and then decreased in a dose-related manner, nocturnal awakenings decreased, and daytime sleep latency increased. Significant improvements in daytime symptoms were measured by the Maintenance of Wakefulness Test, the Epworth Sleepiness Scale, and the narcolepsy symptom questionnaire. Conclusions: Nocturnal administration of sodium oxybate in patients with narcolepsy produces significant improvements in sleep architecture, which coincide with significant improvements in daytime functioning.
引用
收藏
页码:1327 / 1334
页数:8
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