Innate immunity and angiogenesis

被引：168

作者：

Frantz, S

Vincent, KA

Feron, O

Kelly, RA

机构：

[1] Genzyme Corp, Cambridge, MA USA

[2] Univ Wurzburg, Med Klin, D-8700 Wurzburg, Germany

[3] Univ Louvain, Brussels, Belgium

来源：

CIRCULATION RESEARCH | 2005年 / 96卷 / 01期

关键词：

angiogenesis; cytokines; HIF; inflammation;

D O I：

10.1161/01.RES.0000153188.68898.ac

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Activation of an innate immune response is among the first lines of defense after tissue injury. Restoring blood flow to the site of injured tissue is often a necessary prerequisite for mounting an initial immune response to pathogens and for subsequent initiation of a successful repair of wounded tissue. The multiple links among pathogen recognition and suppression, increased angiogenesis, and tissue repair are the topics of this review, which examines of the roles of antimicrobial peptides, mammalian toll-like receptors (TLRs), inflammatory cytokines, and putative "danger" signals, among other signaling pathways, in triggering, sustaining, and then terminating an angiogenic response.

引用

页码：15 / 26

页数：12

共 118 条

[1]

Albina JE, 2003, METH MOLEC MED, V78, P369

[2] Oxygen and the regulation of gene expression in wounds [J].

Albina, JE ;

Reichner, JS .

WOUND REPAIR AND REGENERATION, 2003, 11 (06) :445-451

[3] Role of PIGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 [J].

Autiero, M ;

Waltenberger, J ;

Communi, D ;

Kranz, A ;

Moons, L ;

Lambrechts, D ;

Kroll, J ;

Plaisance, S ;

De Mol, M ;

Bono, F ;

Kliche, S ;

Fellbrich, G ;

Ballmer-Hofer, K ;

Maglione, D ;

Mayr-Beyrle, U ;

Dewerchin, M ;

Dombrowski, S ;

Stanimirovic, D ;

Van Hummelen, P ;

Dehio, C ;

Hicklin, DJ ;

Persico, G ;

Herbert, JM ;

Communi, D ;

Shibuya, M ;

Collen, D ;

Conway, EM ;

Carmeliet, P .

NATURE MEDICINE, 2003, 9 (07) :936-943

[4] Chemokine/chemokine receptor nomenclature [J].

Bacon, K ;

Baggiolini, M ;

Broxmeyer, H ;

Horuk, R ;

Lindley, I ;

Mantovani, A ;

Matsushima, K ;

Murphy, P ;

Nomiyama, H ;

Oppenheim, J ;

Rot, A ;

Schall, T ;

Tsang, M ;

Thorpe, R ;

Van Damme, J ;

Wadhwa, M ;

Yoshie, O ;

Zlotnik, A ;

Zoon, K .

CYTOKINE, 2003, 21 (01) :48-49

[5] Inferences, questions and possibilities in toll-like receptor signalling [J].

Beutler, B .

NATURE, 2004, 430 (6996) :257-263

[6] The subtle side to hypoxia inducible factor (HIFα) regulation [J].

Bilton, RL ;

Booker, GW .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2003, 270 (05) :791-798

[7] Hypoxic gene activation by lipopolysaccharide in macrophages:: Implication of hypoxia-inducible factor 1α [J].

Blouin, CC ;

Pagé, EL ;

Soucy, GM ;

Richard, DE .

BLOOD, 2004, 103 (03) :1124-1130

[8] ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation [J].

Brown, C ;

Gaspar, J ;

Pettit, A ;

Lee, R ;

Gu, XS ;

Wang, H ;

Manning, C ;

Voland, C ;

Goldring, SR ;

Goldring, MB ;

Libermann, TA ;

Gravallese, EM ;

Oettgen, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (13) :12794-12803

[9] Anti-microbial peptides:: from invertebrates to vertebrates [J].

Bulet, P ;

Stöcklin, R ;

Menin, L .

IMMUNOLOGICAL REVIEWS, 2004, 198 :169-184

[10] Bifunctional role for VEGF-induced heme oxygenase-1 in vivo: induction of angiogenesis and inhibition of leukocytic infiltration [J].

Bussolati, B ;

Ahmed, A ;

Pemberton, H ;

Landis, RC ;

Di Carlo, F ;

Haskard, DO ;

Mason, JC .

BLOOD, 2004, 103 (03) :761-766

← 1 2 3 4 5 6 7 8 9 10 →