Innate immunity and angiogenesis

被引：168

作者：

Frantz, S

Vincent, KA

Feron, O

Kelly, RA

机构：

[1] Genzyme Corp, Cambridge, MA USA

[2] Univ Wurzburg, Med Klin, D-8700 Wurzburg, Germany

[3] Univ Louvain, Brussels, Belgium

来源：

CIRCULATION RESEARCH | 2005年 / 96卷 / 01期

关键词：

angiogenesis; cytokines; HIF; inflammation;

D O I：

10.1161/01.RES.0000153188.68898.ac

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Activation of an innate immune response is among the first lines of defense after tissue injury. Restoring blood flow to the site of injured tissue is often a necessary prerequisite for mounting an initial immune response to pathogens and for subsequent initiation of a successful repair of wounded tissue. The multiple links among pathogen recognition and suppression, increased angiogenesis, and tissue repair are the topics of this review, which examines of the roles of antimicrobial peptides, mammalian toll-like receptors (TLRs), inflammatory cytokines, and putative "danger" signals, among other signaling pathways, in triggering, sustaining, and then terminating an angiogenic response.

引用

收藏

页码：15 / 26

页数：12

相关论文

共 118 条

[31] Upregulated hypoxia inducible factor-1α and -2α pathway in rheumatoid arthritis and osteoarthritis [J].

Giatromanolaki, A ;

Sivridis, E ;

Maltezos, E ;

Athanassou, N ;

Papazoglou, D ;

Gatter, KC ;

Harris, AL ;

Koukourakis, MI .

ARTHRITIS RESEARCH & THERAPY, 2003, 5 (04) :R193-R201

[32] HIF-1 in cell cycle regulation, apoptosis, and tumor progression [J].

Goda, N ;

Dozier, SJ ;

Johnson, RS .

ANTIOXIDANTS & REDOX SIGNALING, 2003, 5 (04) :467-473

[33] Controlling the angiogenic switch -: A balance between two distinct TGF-β receptor signaling pathways [J].

Goumans, MJ ;

Lebrin, F ;

Valdimarsdottir, G .

TRENDS IN CARDIOVASCULAR MEDICINE, 2003, 13 (07) :301-307

[34] Redistribution of intracellular oxygen in hypoxia by nitric oxide:: Effect on HIF1α [J].

Hagen, T ;

Taylor, CT ;

Lam, F ;

Moncada, S .

SCIENCE, 2003, 302 (5652) :1975-1978

[35] HoxD3 accelerates wound healing in diabetic mice [J].

Hansen, SL ;

Myers, CA ;

Charboneau, A ;

Young, DM ;

Boudreau, N .

AMERICAN JOURNAL OF PATHOLOGY, 2003, 163 (06) :2421-2431

[36] Inflammation and angiogenesis in osteoarthritis [J].

Haywood, L ;

McWilliams, DF ;

Pearson, CI ;

Gill, SE ;

Ganesan, A ;

Wilson, D ;

Walsh, DA .

ARTHRITIS AND RHEUMATISM, 2003, 48 (08) :2173-2177

[37] Immunology - Dangerous liaisons [J].

Heath, WR ;

Carbone, FR .

NATURE, 2003, 425 (6957) :460-461

[38] Collateral artery growth (arteriogenesis) after experimental arterial occlusion is impaired in mice lacking CC-chemokine receptor-2 [J].

Heil, M ;

Ziegelhoeffer, T ;

Wagner, S ;

Fernández, B ;

Helisch, A ;

Martin, S ;

Tribulova, S ;

Kuziel, WA ;

Bachmann, G ;

Schaper, W .

CIRCULATION RESEARCH, 2004, 94 (05) :671-677

[39] The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium [J].

Heilborn, JD ;

Nilsson, MF ;

Kratz, G ;

Weber, G ;

Sorensen, O ;

Borregaard, N ;

Ståhle-Bäckdahl, M .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2003, 120 (03) :379-389

[40] Interleukin-1β and tumor necrosis factor-α stimulate DNA binding of hypoxia-inducible factor-1 [J].

Hellwig-Bürgel, T ;

Rutkowski, K ;

Metzen, E ;

Fandrey, J ;

Jelkmann, W .

BLOOD, 1999, 94 (05) :1561-1567

← 1 2 3 4 5 6 7 8 9 10 →