The IL-33-ST2-MyD88 axis promotes regulatory Tcell proliferation in the murine liver

被引：19

作者：

Xu, Lei ^{[1
]}

Li, Wei ^{[1
]}

Wang, Xiaofan ^{[1
]}

Zhang, Lina ^{[1
]}

Qi, Qianqian ^{[1
]}

Dong, Liyang ^{[1
]}

Wei, Chuan ^{[1
]}

Pu, Yanan ^{[1
]}

Li, Yalin ^{[1
]}

Zhu, Jifeng ^{[1
]}

Zhou, Sha ^{[1
]}

Liu, Feng ^{[1
]}

Chen, Xiaojun ^{[1
]}

Su, Chuan ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Pathogen Biol & Immunol, Jiangsu Key Lab Pathogen Biol, Nanjing 211166, Jiangsu, Peoples R China

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2018年 / 48卷 / 08期

基金：

中国国家自然科学基金;

关键词：

IL-33; Liver; MyD88; ST2; Treg; T-CELLS; IL-33; DIFFERENTIATION;

D O I：

10.1002/eji.201747402

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Hepatic Foxp3(+) Treg cells are crucial for maintaining local immune homeostasis in the liver. However, the environmental cues required for hepatic Treg cell homeostasis are unclear. In this study, we showed that the IL-33 receptor ST2 was preferentially expressed on Treg cells in the mouse liver, but it was more lowly expressed in the spleen, mesenteric lymph nodes, and blood. More importantly, we found that IL-33 promoted the proliferation of hepatic Treg cells through myeloid differentiation factor MyD88 signaling concomitant with increased cyclin-dependent kinase 4 and cyclin D1 expression. These results suggest that IL-33 is a potential tissue-specific factor controlling Treg cell homeostasis via increased Treg proliferation in the liver.

引用

收藏

页码：1302 / 1307

页数：6

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