Paget disease of bone

被引：224

作者：

Roodman, GD

Windle, JJ

机构：

[1] VA Pittsburgh Healthcare Syst, Pittsburgh, PA 15240 USA

[2] Univ Pittsburgh, Med Ctr, Dept Med, Div Hematol Oncol, Pittsburgh, PA USA

[3] Virginia Commonwealth Univ, Dept Human Genet, Richmond, VA USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 02期

关键词：

D O I：

10.1172/JCI200524281

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Paget disease of bone (PD) is characterized by excessive bone resorption in focal areas followed by abundant new bone formation, with eventual replacement of the normal bone marrow by vascular and fibrous tissue. The etiology of PD is not well understood, but one PD-linked gene and several other susceptibility loci have been identified, and paramyxoviral gene products have been detected in pagetic osteoclasts. In this review, the pathophysiology of PD and evidence for both a genetic and a viral etiology for PD will be discussed.

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页码：200 / 208

页数：9

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