Cytotoxic naphthoquinones and plumbagic acid glucosides from Plumbago zeylanica

被引：83

作者：

Lin, LC ^{[1
]}

Yang, LL ^{[1
]}

Chou, CJ ^{[1
]}

机构：

[1] Natl Res Inst Chinese Med, Taipei 112, Taiwan

来源：

PHYTOCHEMISTRY | 2003年 / 62卷 / 04期

关键词：

Plumbago zeylanica; Plumbaginaceae; plumbagic acid glucoside; naphthoquinone; coumarin; cytotoxicity;

D O I：

10.1016/S0031-9422(02)00519-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two plumbagic acid glucosides, 3'-O-beta-glucopyranosyl plumbagic acid and 3'-O-beta-glucopyranosyl plumbagic acid methylester along with five naphthoquinones (plumbagin, chitranone, maritinone, elliptinone and isoshinanolone), and five coumarins (seselin, 5-methoxyseselin, suberosin, xanthyletin and xanthoxyletin) were isolated from the roots of Plumbago zeylanica. All coumarins were not previously found in this plant. Cytotoxicity of these compounds to Various tumor cells lines was evaluated, and plumbagin significantly suppressed growth of Raji, Calu-1, HeLa, and Wish tumor cell lines. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：619 / 622

页数：4