Maleimide-Based Thiol Reactive Multiarm Star Polymers via Diels-Alder/Retro Diels-Alder Strategy

被引：34

作者：

Gok, Ozgul ^{[1
]}

Durmaz, Hakan ^{[2
]}

Ozdes, Emrah Soner ^{[1
]}

Hizal, Gurkan ^{[2
]}

Tunca, Umit ^{[2
]}

Sanyal, Amitav ^{[1
]}

机构：

[1] Bogazici Univ, Dept Chem, TR-34342 Istanbul, Turkey

[2] Istanbul Tech Univ, Dept Chem, TR-34469 Istanbul, Turkey

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2010年 / 48卷 / 12期

关键词：

atom transfer polymerization; click conjugation; click reaction; dendrimers; Diels-Alder reaction; functionalizaton of polymers; maleimide polymer; multiarm star polymers; star polymers; LIVING RADICAL POLYMERIZATION; DOUBLE CLICK REACTIONS; BLOCK-COPOLYMERS; MULTIFUNCTIONAL INITIATORS; FUNCTIONALIZED POLYMERS; CHEMISTRY; CORE; DOXORUBICIN; DENDRIMERS; IMMOBILIZATION;

D O I：

10.1002/pola.24030

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Multiarm star polymers containing thiol-reactive maleimide groups at their core have been synthesized by utilization of atom transfer radical polymerization (ATRP) of various methacrylates using a masked maleimide containing multiarm initiator One end of the initiator contains multiple halogen groups that produce the star architecture upon polymerization and the other end contains a masked maleimide functional group. Unmasking of the maleimide group after the polymerization provides the thiol reactive maleimide core that is widely used in bioconjugation. Functionalization of the core maleimide group with a thiol containing tripeptide was used to demonstrate facile reactivity of the core of these multiarm polymers under reagent-free conditions (C) 2010 Wiley Periodicals, Inc J Polym Sci Part A. Polym Chem 48 2546-2556, 2010

引用

页码：2546 / 2556

页数：11

共 56 条

[1] Atom transfer radical polymerization of styrene using a novel octafunctional initiator: Synthesis of well-defined polystyrene stars [J].