Transungual drug delivery: Current status

被引：53

作者：

Elkeeb, Rania ^{[1
]}

AliKhan, Ali ^{[2
]}

Elkeeb, Laila ^{[3
]}

Hui, Xiaoying ^{[1
]}

Maibach, Howard I. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Dermatol, Sch Med, San Francisco, CA 94143 USA

[2] Univ Calif Davis, Sch Med, Davis, CA 95616 USA

[3] Univ Calif Irvine, Dept Dermatol, Sch Med, Irvine, CA 92717 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2010年 / 384卷 / 1-2期

关键词：

Ungual drug delivery; Onychomycosis; Nail penetration; Antifungal; Onychopharmacokinetics; HUMAN NAIL PLATE; HUMAN STRATUM-CORNEUM; IN-VITRO; TOENAIL ONYCHOMYCOSIS; ANTIFUNGAL THERAPY; PENETRATION; PERMEATION; PERMEABILITY; CICLOPIROX; WATER;

D O I：

10.1016/j.ijpharm.2009.10.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Topical therapy is highly desirable in treating nail disorders due to its localized effects, which results in minimal adverse systemic events and possibly improved adherence. However, the effectiveness of topical therapies is limited by minimal drug permeability through the nail plate. Current research on nail permeation that focuses on altering the nail plate barrier by means of chemical treatments, penetration enhancers as well as physical and mechanical methods is reviewed. A new method of nail sampling is examined. Finally limitations of current ungual drug permeability studies are briefly discussed. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：1 / 8

页数：8

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