Histone Modifications: Crucial Elements for Damage Response and Chromatin Restoration

被引：47

作者：

Zhu, Qianzheng ^{[1
]}

Wani, Altaf A. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Ohio State Univ, Dept Radiol, Columbus, OH 43240 USA

[2] Ohio State Univ, Dept Mol & Cellular Biochem, Columbus, OH 43240 USA

[3] Ohio State Univ, Solove Res Inst, Columbus, OH 43240 USA

[4] James Canc Hosp, Columbus, OH USA

[5] King Saud Univ, Coll Sci, Riyadh 11451, Saudi Arabia

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2010年 / 223卷 / 02期

关键词：

DNA-REPLICATION; H2A UBIQUITINATION; REPAIR; PROTEIN; ACETYLATION; RNF8; H3; SITES; MDC1; UBIQUITYLATION;

D O I：

10.1002/jcp.22060

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic genomes are packaged into chromatin from repeated nucleosome arrays in which DNA sequences wrap around histones. Chromatin organization has profound influence on DNA-templated processes such as transcription, DNA replication, and repair. Recent studies have also revealed chromatin dynamics as an active contributor to diverse DNA damage responses (DDR). Here, we review recent progress in histone modification related to DDR and post-repair chromatin restoration at the sites of DNA damage. We discuss how the timing and features of histone modifications would provide the initial as well as the final guidance for DDR, and the prospect that modifications may challenge the epigenetic stability of repaired cells and serve as damage memory in chromatin. J. Cell. Physiol. 223: 283-288, 2010. (c) 2010 Wiley-Liss, Inc.

引用

页码：283 / 288

页数：6

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