Comparison of Broth Microdilution, Agar Dilution, and Etest for Susceptibility Testing of Doripenem against Gram-Negative and Gram-Positive Pathogens

被引:21
作者
Amsler, K. [1 ]
Santoro, C.
Foleno, B.
Bush, K. [2 ]
Flamm, R.
机构
[1] Johnson & Johnson Pharmaceut Res & Dev LLC, Infect Dis & Vaccines, Raritan, NJ 08869 USA
[2] Indiana Univ, Bloomington, IN USA
关键词
CARBAPENEM;
D O I
10.1128/JCM.00494-10
中图分类号
Q93 [微生物学];
学科分类号
071005 [微生物学];
摘要
The susceptibility of 513 clinical isolates to doripenem was determined by broth microdilution, agar dilution, and Etest. Overall agreements for Etest and agar dilution MIC values compared to reference broth microdilution at +/-1 log(2) dilution were 88% and 94%, respectively. Etest MIC values demonstrated 98% agreement within +/-2 log(2) dilutions compared to the reference broth microdilution method.
引用
收藏
页码:3353 / 3357
页数:5
相关论文
共 9 条
[1]
AMSLER K, 2007, 47 INT C ANT AG CHEM
[2]
[Anonymous], M7A7 CLIN LAB STAND
[3]
[Anonymous], M100S17 CLIN LAB STA
[4]
BADAL R, 2008, 108 GEN M AM SOC MIC
[5]
Antimicrobial activities of doripenem and other carbapenems against Pseudomonas aeruginosa, other nonfermentative bacilli, and Aeromonas spp. [J].
Castanheira, Mariana ;
Jones, Ronald N. ;
Livermore, David M. .
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, 2009, 63 (04) :426-433
[6]
Clinical and Laboratory Standards Institute, 2009, M100S19 CLIN LAB STA, V29
[7]
In vitro antimicrobial activity of doripenem, a new carbapenem [J].
Ge, YG ;
Wikler, MA ;
Sahm, DF ;
Blosser-Middleton, RS ;
Karlowsky, JA .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (04) :1384-1396
[8]
Doripenem (S-4661), a novel carbapenem:: comparative activity against contemporary pathogens including bactericidal action and preliminary in vitro methods evaluations [J].
Jones, RN ;
Huynh, HK ;
Biedenbach, DJ ;
Fritsche, TR ;
Sader, HS .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2004, 54 (01) :144-154
[9]
In vitro activity of doripenem against Acinetobacter baumannii clinical isolates [J].
Marti, Sara ;
Sanchez-Cespedes, Javier ;
Alba, Veronica ;
Vila, Jordi .
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2009, 33 (02) :181-182