Estrogens, inflammation and cognition

被引：123

作者：

Au, April ^{[1
]}

Feher, Anita ^{[1
]}

McPhee, Lucy ^{[1
]}

Jessa, Ailya ^{[1
]}

Oh, Soojin ^{[1
]}

Einstein, Gillian ^{[1
]}

机构：

[1] Univ Toronto, Dept Psychol, 100 St George St,4F Sidney Smith Hall, Toronto, ON M5S 3G3, Canada

来源：

FRONTIERS IN NEUROENDOCRINOLOGY | 2016年 / 40卷

关键词：

Estrogens; Hormone therapy; Inflammation; Neuroinflammation; Cognition; Dementia; HORMONE REPLACEMENT THERAPY; BLOOD-BRAIN-BARRIER; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; LONG-TERM POTENTIATION; BREAST-CANCER RISK; NF-KAPPA-B; ALZHEIMERS-DISEASE; POSTMENOPAUSAL WOMEN; SURGICAL MENOPAUSE; MULTIPLE-SCLEROSIS;

D O I：

10.1016/j.yfrne.2016.01.002

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

The effects of estrogens are pleiotropic, affecting multiple bodily systems. Changes from the body's natural fluctuating levels of estrogens, through surgical removal of the ovaries, natural menopause, or the administration of exogenous estrogens to menopausal women have been independently linked to an altered immune profile, and changes to cognitive processes. Here, we propose that inflammation may mediate the relationship between low levels of estrogens and cognitive decline. In order to determine what is known about this connection, we review the literature on the cognitive effects of decreased estrogens due to oophorectomy or natural menopause, decreased estrogens' role on inflammation - both peripherally and in the brain - and the relationship between inflammation and cognition. While this review demonstrates that much is unknown about the intersection between estrogens, cognition, inflammation, we propose that there is an important interaction between these literatures. Crown Copyright (C) 2016 Published by Elsevier Inc.

引用

页码：87 / 100

页数：14

共 195 条

[91]

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation [J].