Thrombin signalling and protease-activated receptors

被引：2055

作者：

Coughlin, SR

机构：

[1] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Pharmacol, San Francisco, CA 94143 USA

来源：

NATURE | 2000年 / 407卷 / 6801期

关键词：

D O I：

10.1038/35025229

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

How does the coagulation protease thrombin regulate cellular behaviour? The protease-activated receptors (PARs) provide one answer. In concert with the coagulation cascade, these receptors provide an elegant mechanism linking mechanical information in the form of tissue injury or vascular leakage to cellular responses. Roles for PARs are beginning to emerge in haemostasis and thrombosis, inflammation, and perhaps even blood vessel development.

引用

页码：258 / 264

页数：7

共 64 条

[61] Regulation of the actin cytoskeleton by thrombin in human endothelial cells:: Role of Rho proteins in endothelial barrier function [J].