Cyclooxygenase-2:: a therapeutic target in angiogenesis

被引：174

作者：

Iñiguez, MA

Rodríguez, A

Volpert, OV

Fresno, M

Redondo, JM

机构：

[1] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, Fac Ciencias, E-28049 Madrid, Spain

[2] Ctr Nacl Invest Cardiovasc, E-28029 Madrid, Spain

[3] Dept Urol, Chicago, IL 60611 USA

[4] Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

来源：

TRENDS IN MOLECULAR MEDICINE | 2003年 / 9卷 / 02期

关键词：

D O I：

10.1016/S1471-4914(02)00011-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Angiogenesis has a role in the pathogenesis of several disorders, including cancer, chronic inflammatory diseases and retinopathies. Recent evidence demonstrates that the production of prostanoids by cyclooxygenase-2 (COX-2) promotes the expression of pro-angiogenic factors. Furthermore, inhibition of COX-2 by non-steroidal anti-inflammatory drugs leads to restricted angiogenesis and downregulated production of pro-angiogenic factors, such as vascular endothelial growth factor and basic fibroblast growth factor. These findings suggest that COX enzymes could be important therapeutic targets in the treatment of pathological angiogenesis.

引用

页码：73 / 78

页数：6

共 61 条

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