The developing heart and congenital heart defects: a make or break situation

被引：33

作者：

Bruneau, BG

机构：

[1] Hosp Sick Children, Dept Mol & Med Genet, Program Cardiovasc Res, Toronto, ON M5G 1X8, Canada

[2] Hosp Sick Children, Dept Mol & Med Genet, Program Dev Biol, Toronto, ON M5G 1X8, Canada

[3] Univ Toronto, Heart & Stroke Richard Lewar Ctr Cardiovasc Res, Toronto, ON, Canada

来源：

CLINICAL GENETICS | 2003年 / 63卷 / 04期

关键词：

congenital heart defects; embryo; gene expression; heart; morphogenesis;

D O I：

10.1034/j.1399-0004.2003.00066.x

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Congenital heart defects are common in humans, but the underlying basis for these defects is not well understood. It has been clear that abnormal heart development is at the root of these diseases, but the genes involved have remained elusive until recently. This review focuses on recent advances in our understanding of mammalian heart formation, and how some of these processes, when disrupted, lead to congenital heart defects.

引用

收藏

页码：252 / 261

页数：10

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