Expression of a system L neutral amino acid transporter at the blood-brain barrier

被引：121

作者：

Matsuo, H

Tsukada, S

Nakata, T

Chairoungdua, A

Kim, DK

Cha, SH

Inatomi, J

Yorifuji, H

Fukuda, J

Endou, H

Kanai, Y

机构：

[1] Kyorin Univ, Sch Med, Dept Pharmacol & Toxicol, Tokyo 1818611, Japan

[2] Natl Def Med Coll, Dept Physiol 1, Tokorozawa, Saitama 3598513, Japan

[3] Natl Def Med Coll, Dept Anat, Tokorozawa, Saitama 3598513, Japan

[4] PRESTO, Japan Sci & Technol Corp, Kyoto, Japan

来源：

NEUROREPORT | 2000年 / 11卷 / 16期

关键词：

amino acid; blood-brain barrier; L-DOPA; 4F2 heavy chain; system L; transporter;

D O I：

10.1097/00001756-200011090-00021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Amino acid transport system L has been proposed to be one of the major nutrient transport systems at the blood-brain barrier. Using immunohistochemical analyses, a system L transporter LAT1 was shown to be expressed in the brain capillary endothelial cells in rats. Because LAT1 was coexpressed with 4F2 heavy chain which brings LAT1 to the plasma membrane, LAT1 is proposed to be functional in the plasma membrane of brain capillary endothelial cells. Both LAT1 and 4F2hc immunoreactivities were detected in-a double line appearance surrounding endothelial cell nuclei, suggesting both proteins are present in the luminal and abluminal membranes. LAT1 is, thus, a blood-brain-barrier system L transporter responsible for the permeation of aromatic or branched-chain amino acids and amino acid-related drugs such as L-DOPA. NeuroReport 11:3507-3511 (C) 2000 Lippincott Williams & Wilkins.

引用

页码：3507 / 3511

页数：5

共 24 条

[11] THE BLOOD-BRAIN-BARRIER [J].