Laccases: a never-ending story

被引:773
作者
Giardina, Paola [1 ]
Faraco, Vincenza [1 ]
Pezzella, Cinzia [1 ]
Piscitelli, Alessandra [1 ]
Vanhulle, Sophie [2 ]
Sannia, Giovanni [1 ]
机构
[1] Complesso Univ Monte S Angelo, Dipartimento Chim Organ & Biochem, I-80126 Naples, Italy
[2] Catholic Univ Louvain, Microbiol Unit, B-1348 Louvain, Belgium
关键词
Multicopper oxidases; Laccase structures; Unusual laccases; Laccase gene family; Laccase regulation; FUNGUS PLEUROTUS-OSTREATUS; RHUS-VERNICIFERA LACCASE; O-O BOND; MULTICOPPER-BLUE-PROTEINS; TRINUCLEAR CU CLUSTER; MULTI-COPPER OXIDASES; GRAMINIS VAR. TRITICI; X-RAY-STRUCTURE; CRYSTAL-STRUCTURE; SACCHAROMYCES-CEREVISIAE;
D O I
10.1007/s00018-009-0169-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Laccases (benzenediol:oxygen oxidoreductases, EC 1.10.3.2) are blue multicopper oxidases that catalyze the oxidation of an array of aromatic substrates concomitantly with the reduction of molecular oxygen to water. In fungi, laccases carry out a variety of physiological roles during their life cycle. These enzymes are being increasingly evaluated for a variety of biotechnological applications due to their broad substrate range. In this review, the most recent studies on laccase structural features and catalytic mechanisms along with analyses of their expression are reported and examined with the aim of contributing to the discussion on their structure-function relationships. Attention has also been paid to the properties of enzymes endowed with unique characteristics and to fungal laccase multigene families and their organization.
引用
收藏
页码:369 / 385
页数:17
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