An efficient method for the synthesis of 3-cyano-6-hydroxy-2(1H)-pyridinones under microwave irradiation and solvent-free conditions

被引：14

作者：

Balalaie, S

Kowsari, E

Hashtroudi, MS

机构：

[1] KN Toosi Univ Technol, Dept Chem, Tehran, Iran

[2] Mat & Energy Res Ctr, Energy & Environm Dept, Tehran, Iran

来源：

MONATSHEFTE FUR CHEMIE | 2003年 / 134卷 / 03期

关键词：

solvent-free organic synthesis; microwave chemistry; cyclocondensation; 2-pyridinones;

D O I：

10.1007/s00706-002-0551-2

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Three component condensation of alkylacetoacetates, primary amines, and alkyl cyanoacetates catalyzed by solid supports under microwave irradiation gave N-alkyl 3-cyano-6-hydroxy-2(1H)-pyridinones with high yields. Upon carrying out the reaction under the same condition on acidic alumina, zeolite HY, silica gel, and montmorillonite K-10, the best yields were achieved by silica gel.

引用

页码：453 / 456

页数：4

共 33 条

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