Helicase structures: a new twist on DNA unwinding

被引：22

作者：

Marians, KJ

机构：

[1] Molecular Biology Program, Mem. Sloan-Kettering Cancer Center, New York, NY 10021

来源：

STRUCTURE | 1997年 / 5卷 / 09期

关键词：

D O I：

10.1016/S0969-2126(97)00263-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal structures of two members of the SF1 family of helicases, Rep and PcrA, and one member of the SF2 family of helicases, the HCV RNA helicase, have recently been solved. These structures illuminate the roles of the conserved helicase motifs in catalytic function and offer clues as to how these proteins can translocate along DNA.

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页码：1129 / 1134

页数：6

相关论文

共 13 条

[1] ENZYMIC UNWINDING OF DNA .2. CHAIN SEPARATION BY AN ATP-DEPENDENT DNA UNWINDING ENZYME [J].

ABDELMONEM, M ;

DURWALD, H ;

HOFFMANNBERLING, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1976, 65 (02) :441-449

[2] Kinetic measurement of the step size of DNA unwinding by Escherichia coli UvrD helicase [J].

Ali, JA ;

Lohman, TM .

SCIENCE, 1997, 275 (5298) :377-380

[3]

BROSH RM, 1996, J BIOL CHEM, V271, P25630

[4] HELICASES - AMINO-ACID-SEQUENCE COMPARISONS AND STRUCTURE-FUNCTION-RELATIONSHIPS [J].

GORBALENYA, AE ;

KOONIN, EV .

CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (03) :419-429

[5] Major domain swiveling revealed by the crystal structures of complexes of E-coli Rep helicase bound to single-stranded DNA and ADP [J].

Korolev, S ;

Hsieh, J ;

Gauss, GH ;

Lohman, TM ;

Waksman, G .

CELL, 1997, 90 (04) :635-647

[6] Mechanisms of helicase-catalyzed DNA unwinding [J].

Lohman, TM ;

Bjornson, KP .

ANNUAL REVIEW OF BIOCHEMISTRY, 1996, 65 :169-214

[7]

MATSON SW, 1990, ANNU REV BIOCHEM, V59, P289, DOI 10.1146/annurev.biochem.59.1.289

[8] ENZYME-SYSTEM FOR REPLICATION OF DUPLEX CIRCULAR DNA - REPLICATIVE FORM OF PHAGE PHIX174 .3. MECHANISM OF DUPLEX DNA-REPLICATION REVEALED BY ENZYMATIC STUDIES OF PHAGE PHIX174 - CATALYTIC STRAND SEPARATION IN ADVANCE OF REPLICATION [J].

SCOTT, JF ;

EISENBERG, S ;

BERTSCH, LL ;

KORNBERG, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (01) :193-197

[9] Crystal structure of a DExx box DNA helicase [J].

Subramanya, HS ;

Bird, LE ;

Brannigan, JA ;

Wigley, DB .

NATURE, 1996, 384 (6607) :379-383

[10] DISTANTLY RELATED SEQUENCES IN THE ALPHA-SUBUNITS AND BETA-SUBUNITS OF ATP SYNTHASE, MYOSIN, KINASES AND OTHER ATP-REQUIRING ENZYMES AND A COMMON NUCLEOTIDE BINDING FOLD [J].

WALKER, JE ;

SARASTE, M ;

RUNSWICK, MJ ;

GAY, NJ .

EMBO JOURNAL, 1982, 1 (08) :945-951