Synthase (H+ ATPase):: coupling between catalysis, mechanical work, and proton translocation

被引：40

作者：

Futai, M ^{[1
]}

Omote, H ^{[1
]}

Sambongi, Y ^{[1
]}

Wada, Y ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Div Biol Sci, Japan Sci & Technol Corp,CREST, Osaka 5670047, Japan

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2000年 / 1458卷 / 2-3期

关键词：

F0F1; catalytic site; ATP synthesis; proton transport; HC ATPase; rotational catalysis;

D O I：

10.1016/S0005-2728(00)00080-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Coupling with electrochemical proton gradient, ATP synthase (F0F1) synthesizes ATP from ADP and phosphate. Mutational studies on high-resolution structure have been useful in understanding this complicated membrane enzyme. We discuss mainly the mechanism of catalysis in the beta subunit of F-1 sector and roles of the gamma subunit in energy coupling. The gamma-subunit rotation during catalysis is also discussed. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：276 / 288

页数：13

相关论文

共 73 条

[31] ALPHA-3-BETA-3 COMPLEX OF THERMOPHILIC ATP SYNTHASE - CATALYSIS WITHOUT THE GAMMA-SUBUNIT [J].

KAGAWA, Y ;

OHTA, S ;

OTAWARAHAMAMOTO, Y .

FEBS LETTERS, 1989, 249 (01) :67-69

[32] DELETION OF 7 AMINO-ACID RESIDUES FROM THE GAMMA-SUBUNIT OF ESCHERICHIA-COLI H+-ATPASE CAUSES TOTAL LOSS OF F1-ASSEMBLY ON MEMBRANES [J].

KANAZAWA, H ;

HAMA, H ;

ROSEN, BP ;

FUTAI, M .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1985, 241 (02) :364-370

[33] Direct observation of the rotation of ε subunit in F1-ATPase [J].

Kato-Yamada, Y ;

Noji, H ;

Yasuda, R ;

Kinosita, K ;

Yoshida, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (31) :19375-19377

[34] MOLSCRIPT - A PROGRAM TO PRODUCE BOTH DETAILED AND SCHEMATIC PLOTS OF PROTEIN STRUCTURES [J].

KRAULIS, PJ .

JOURNAL OF APPLIED CRYSTALLOGRAPHY, 1991, 24 :946-950

[35]

LE NP, 2000, IN PRESS BIOCHEMISTR

[36] F-1-ATPase, roles of three catalytic site residues [J].

Lobau, S ;

Weber, J ;

WilkeMounts, S ;

Senior, AE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (06) :3648-3656

[37] Nucleotide occupancy of F-1-ATPase catalytic sites under crystallization conditions [J].

Lobau, S ;

Weber, J ;

Senior, AE .

FEBS LETTERS, 1997, 404 (01) :15-18

[38]

MAGGIO MB, 1987, J BIOL CHEM, V262, P8981

[39] ESCHERICHIA-COLI H+-ATPASE - LOSS OF THE CARBOXYL TERMINAL REGION OF THE GAMMA-SUBUNIT CAUSES DEFECTIVE ASSEMBLY OF THE F1 PORTION [J].

MIKI, J ;

TAKEYAMA, M ;

NOUMI, T ;

KANAZAWA, H ;

MAEDA, M ;

FUTAI, M .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1986, 251 (02) :458-464

[40] TEMPERATURE-SENSITIVE ESCHERICHIA-COLI MUTANT WITH AN ALTERED INITIATION CODON OF THE UNCG GENE FOR THE H+ -ATPASE GAMMA-SUBUNIT [J].

MIKI, J ;

MAEDA, M ;

FUTAI, M .

JOURNAL OF BACTERIOLOGY, 1988, 170 (01) :179-183

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