Influence of oxygen tension on myocardial performance. Evaluation by tissue Doppler imaging

被引：30

作者：

Frøbert O. ^{[1
,2
]}

Moesgaard J. ^{[1
]}

Toft E. ^{[3
]}

Poulsen S.H. ^{[4
]}

Søgaard P. ^{[1
]}

机构：

[1] Department of Cardiology, Aalborg Hospital, Aarhus University Hospital

[2] Institute of Pharmacology, University of Aarhus

[3] Ctr. Model-based Med. Decis. S., Dept. of Hlth. Sci. and Technology, Aalborg University, Aalborg

[4] Skejby University Hospital, Aarhus

来源：

Cardiovascular Ultrasound | / 2卷 / 1期

关键词：

Diastolic Function; Tricuspid Regurgitation; Tissue Doppler Imaging; Left Ventricular Filling Pressure; Myocardial Performance;

D O I：

10.1186/1476-7120-2-22

中图分类号：

学科分类号：

摘要：

Background: Low O2 tension dilates coronary arteries and high O2 tension is a coronary vasoconstrictor but reports on O 2-dependent effects on ventricular performance diverge. Yet oxygen supplementation remains first line treatment in cardiovascular disease. We hypothesized that hypoxia improves and hyperoxia worsens myocardial performance. Methods: Seven male volunteers (mean age 38 ± 3 years) were examined with echocardiography at respiratory equilibrium during: 1) normoxia (≈21% O2, 79% N2), 2) while inhaling a hypoxic gas mixture (≈11% O2, 89% N2), and 3) while inhaling 100% O 2. Tissue Doppler recordings were acquired in the apical 4-chamber, 2-chamber, and long-axis views. Strain rate and tissue tracking displacement analyses were carried out in each segment of the 16-segment left ventricular model and in the basal, middle and apical portions of the right ventricle. Results: Heart rate increased with hypoxia (68 ± 4 bpm at normoxia vs. 79 ± 5 bpm, P < 0.001) and decreased with hyperoxia (59 ± 5 bpm, P < 0.001 vs. normoxia). Hypoxia increased strain rate in four left ventricular segments and global systolic contraction amplitude was increased (normoxia: 9.76 ± 0.41 vs hypoxia: 10.87 ± 0.42, P < 0.001). Tissue tracking displacement was reduced in the right ventricular segments and tricuspid regurgitation increased with hypoxia (7.5 ± 1.9 mmHg vs. 33.5 ± 1.8 mmHg, P < 0.001). The TEI index and E/E' did not change with hypoxia. Hyperoxia reduced strain rate in 10 left ventricular segments, global systolic contraction amplitude was decreased (8.83 ± 0.38, P < 0.001 vs. normoxia) while right ventricular function was unchanged. The spectral and tissue Doppler TEI indexes were significantly increased but E/E' did not change with hyperoxia. Conclusion: Hypoxia improves and hyperoxia worsens systolic myocardial performance in healthy male volunteers. Tissue Doppler measures of diastolic function are unaffected by hypoxia/hyperoxia which support that the changes in myocardial performance are secondary to changes in vascular tone. It remains to be settled whether oxygen therapy to patients with heart disease is a consistent rational treatment. © 2004 Frøbert et al; licensee BioMed Central Ltd.

引用

共 27 条

[21]

Crawford P., Good P.A., Gutierrez E., Feinberg J.H., Boehmer J.P., Silber D.H., Sinoway L.I., Effects of supplemental oxygen on forearm vasodilation in humans, J Appl Physiol, 82, pp. 1601-1606, (1997)

[22]

Kenmure A.C., Murdoch W.R., Beattie A.D., Marshall J.C., Cameron A.J., Circulatory and metabolic effects of oxygen in myocardial infarction, Br Med J, 4, pp. 360-364, (1968)

[23]

Benedict F.G., Higgins H.L., Effects on men at rest of breathing oxygen-rich gas mixtures, Am J Physiol, 28, pp. 1-28, (1911)

[24]

Barratt-Boyes B.G., Wood E.H., Cardiac output and related measurements and pressure values in the right heart and associated vessels, together with an analysis of the hemo-dynamic response to the inhalation of high oxygen mixtures in healthy subjects, J Lab Clin Med, 51, pp. 72-90, (1958)

[25]

Alveryd A., Brody S., Cardiovascular and respiratory changes in man during oxygen breathing, Acta Physiol Scand, 15, pp. 140-149, (1948)

[26]

Daniell H.B., Bagwell E.E., Effects of high oxygen on coronary flor and heart force, Am J Physiol, 214, pp. 1454-1459, (1968)

[27]

Andersen N.H., Poulsen S.H., Evaluation of the longitudinal contraction of the left ventricle in normal subjects by Doppler tissue tracking and strain rate, J Am Soc Echocardiogr, 16, pp. 716-723, (2003)

← 1 2 3 →