学术探索
学术期刊
新闻热点
数据分析
智能评审

Diabetes in African Americans: Unique pathophysiologic features

被引：23
作者：
Banerji M.A. [1 ]
机构：
[1] SUNY Health Science Center, Brooklyn, NY 11203
来源：
Current Diabetes Reports | 2004年 / 4卷 / 3期
关键词：
Metabolic Syndrome; Visceral Adipose Tissue; Repaglinide; Diabetic Ketoacidosis; Glipizide;
D O I：
10.1007/s11892-004-0027-3
中图分类号：
学科分类号：
摘要：
Type 2 diabetes is an increasing public health problem among African Americans, especially children. Several features make type 2 diabetes among African Americans unique. First, African-American adults with type 2 diabetes, or Flatbush diabetes, present with diabetic ketoacidosis. Patients are insulin resistant with acute, severe defects in insulin secretion and no islet cell autoantibodies. Following treatment, some insulin secretory capacity is recovered and ketoacidosis generally does not recur. The second is remission in African Americans with type 2 diabetes. Recovery of glucose homeostasis, accompanied by recovery of β-cell function, follows intensive glycemic regulation. Finally, among African Americans with diabetes who are not obese, normal insulin sensitivity is not uncommon. Such individuals do not have the increased cardiovascular risk of insulin-resistant individuals. Differences in visceral, not subcutaneous, adipose tissue volume appear to determine insulin sensitivity. Understanding the unique physiologic and clinical features of African Americans is critical in designing appropriate treatment strategies. Copyright © 2004 by Current Science Inc.
引用
收藏
页码：219 / 223
页数：4
相关论文
共 55 条
  • [51] Arslanian S., Metabolic differences between Caucasian and African-American children and the relationship to type 2 diabetes mellitus, J. Pediatr. Endocrinol. Metab., 15, SUPPL. 2, pp. 509-517, (2002)
  • [52] Bacha F., Saad R., Gungor N., Et al., Obesity, regional fat distribution, and syndrome X in obese black versus white adolescents: Race differential in diabetogenic and atherogenic risk factors, J. Clin. Endocrinol. Metab., 88, pp. 2534-2540, (2003)
  • [53] Steinberger J., Daniels S.R., Obesity, insulin resistance, diabetes, and cardiovascular risk in children: An American Heart Association scientific statement from the Atherosclerosis, Hypertension, and Obesity in the Young Committee (Council on Cardiovascular Disease in the Young) and the Diabetes Committee (Council on Nutrition, Physical Activity, and Metabolism), Circulation, 107, pp. 1448-1453, (2003)
  • [54] Apedo M.T., Sowers J.R., Banerji M., Cardiovascular disease in adolescents with type 2 diabetes mellitus, J. Pediatr. Endocrinol. Metab., 15, SUPPL. 1, pp. 519-523, (2002)
  • [55] Banerji M.A., Impaired beta-cell and alpha-cell function in African-American children with type 2 diabetes mellitus - 'Flatbush diabetes, J. Pediatr. Endocrinol. Metab., 15, SUPPL. 1, pp. 493-501, (2002)
123456