Consanguinity and reproductive health among Arabs

被引：377

作者：

Tadmouri G.O. ^{[1
]}

Nair P. ^{[1
]}

Obeid T. ^{[1
]}

Al Ali M.T. ^{[1
]}

Al Khaja N. ^{[1
]}

Hamamy H.A. ^{[1
,2
]}

机构：

[1] Centre for Arab Genomic Studies, Dubai

[2] Geneva Foundation for Medical Education and Research, Geneva

来源：

Reproductive Health | / 6卷 / 1期

关键词：

Spinal Muscular Atrophy; Arab Country; Consanguineous Marriage; Congenital Heart Defect; Consanguineous Parent;

D O I：

10.1186/1742-4755-6-17

中图分类号：

学科分类号：

摘要：

Consanguineous marriages have been practiced since the early existence of modern humans. Until now consanguinity is widely practiced in several global communities with variable rates depending on religion, culture, and geography. Arab populations have a long tradition of consanguinity due to socio-cultural factors. Many Arab countries display some of the highest rates of consanguineous marriages in the world, and specifically first cousin marriages which may reach 25-30% of all marriages. In some countries like Qatar, Yemen, and UAE, consanguinity rates are increasing in the current generation. Research among Arabs and worldwide has indicated that consanguinity could have an effect on some reproductive health parameters such as postnatal mortality and rates of congenital malformations. The association of consanguinity with other reproductive health parameters, such as fertility and fetal wastage, is controversial. The main impact of consanguinity, however, is an increase in the rate of homozygotes for autosomal recessive genetic disorders. Worldwide, known dominant disorders are more numerous than known recessive disorders. However, data on genetic disorders in Arab populations as extracted from the Catalogue of Transmission Genetics in Arabs (CTGA) database indicate a relative abundance of recessive disorders in the region that is clearly associated with the practice of consanguinity. © 2009 Tadmouri et al.

引用

共 139 条

[41]

Mahdi A., Consanguinity and its effect on major congenital malformations, Iraqi Med J, 40-42, pp. 170-176, (1992)

[42]

Khoury S.A., Massad D.F., Consanguinity, fertility, reproductive wastage, infant mortality and congenital malformations in Jordan, Saudi Med J, 21, pp. 150-154, (2000)

[43]

Obeidat B.R., Khader Y.S., Amarin Z.O., Kassawneh M., Al O.M., Consanguinity and Adverse Pregnancy Outcomes: The North of Jordan Experience, Matern Child Health J, (2008)

[44]

Temtamy S.A., Abdel Meguid N., Mazen I., Ismail S.R., Kassem N.S., Bassiouni R., A genetic epidemiological study of malformations at birth in Egypt, East Mediterr Health J, 4, pp. 252-259, (1998)

[45]

Bittar Z., Major congenital malformations presenting in the first 24 hours of life in 3865 consecutive births in south of Beirut. Incidence and pattern, J Med Liban, 46, pp. 256-260, (1998)

[46]

Khrouf N., Spang R., Podgorna T., Miled S.B., Moussaoui M., Chibani M., Malformations in 10,000 consecutive births in Tunis, Acta Paediatr Scand, 75, pp. 534-539, (1986)

[47]

El Mouzan M.I., Al Salloum A.A., Al Herbish A.S., Qurachi M.M., Al Omar A.A., Consanguinity and major genetic disorders in Saudi children: A community-based cross-sectional study, Ann Saudi Med, 28, pp. 169-173, (2008)

[48]

Yunis K., Mumtaz G., Bitar F., Chamseddine F., Kassar M., Rashkidi J., Et al., Consanguineous marriage and congenital heart defects: A case-control study in the neonatal period, Am J Med Genet A, 140, pp. 1524-1530, (2006)

[49]

Nabulsi M.M., Tamim H., Sabbagh M., Obeid M.Y., Yunis K.A., Bitar F.F., Parental consanguinity and congenital heart malformations in a developing country, Am J Med Genet A, 116, pp. 342-347, (2003)

[50]

Seliem M.A., Bou-Holaigah I.H., Al-Sannaa N., Influence of consanguinity on the pattern of familial aggregation of congenital cardiovascular anomalies in an outpatient population: Studies from the eastern province of Saudi Arabia, Community Genet, 10, pp. 27-31, (2007)

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