Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts

被引：76

作者：

Braidy N. ^{[1
,2
]}

Gai W.-P. ^{[3
]}

Xu Y.H. ^{[2
,4
]}

Sachdev P. ^{[1
,5
]}

Guillemin G.J. ^{[6
,7
]}

Jiang X.-M. ^{[8
]}

Ballard J.W.O. ^{[9
]}

Horan M.P. ^{[9
]}

Fang Z.M. ^{[8
]}

Chong B.H. ^{[8
]}

Chan D.K.Y. ^{[2
,3
,10
]}

机构：

[1] Centre for Healthy Brain Ageing, School of Psychiatry, University of New South Wales, Sydney

[2] Aged Care and Rehabilitation, Bankstown-Lidcombe Hospital, Sydney

[3] Department of Human Physiology and Centre for Neuroscience, Flinders University School of Medicine, Adelaide

[4] Faculty of Medicine, University of New South Wales, Sydney

[5] Neuropsychiatric Institute, Prince of Wales Hospital, Sydney

[6] School of Medical Sciences, University of New South Wales, Sydney

[7] St Vincent's Centre for Applied Medical Research, Sydney

[8] St George Clinical School, University of New South Wales and St George Hospital, Sydney

[9] School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney

[10] Aged Care and Rehabilitation Unit, Bankstown-Lidcombe Hospital, Bankstown, 2031, NSW, Eldridge Road

来源：

Translational Neurodegeneration | / 2卷 / 1期

基金：

英国医学研究理事会;

关键词：

Alpha-synuclein; Astrocytes; Fibroblasts; Mitochondria; Neurons;

D O I：

10.1186/2047-9158-2-20

中图分类号：

学科分类号：

摘要：

The accumulation and aggregation of alpha-synuclein (α-syn) in several tissue including the brain is a major pathological hallmark in Parkinson's disease (PD). In this study, we show that α-syn can be taken up by primary human cortical neurons, astrocytes and skin-derived fibroblasts in vitro. Our findings that brain and peripheral cells exposed to α-syn can lead to impaired mitochondrial function, leading to cellular degeneration and cell death, provides additional evidence for the involvement of mitochondrial dysfunction as a mechanism of toxicity of α-syn in human cells. © 2013 Braidy et al.; licensee BioMed Central Ltd.

引用

共 41 条

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