Expression of complement receptor type 1 (CR1) on erythrocytes of paracoccidiodomycosis patients

被引：5

作者：

Teixeira J.E. ^{[1
]}

Martinez R. ^{[2
]}

Câmara L.M.C. ^{[3
]}

Barbosa J.E. ^{[1
]}

机构：

[1] Department of Parasitology, Microbiology and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP

[2] Department of Internal Medicine, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP

[3] Federal University of Ceará, Fortaleza, CE

来源：

Mycopathologia | 2001年 / 152卷 / 3期

关键词：

CR1 (complement receptor type 1); CRP (C reactive protein); HAIgG (heat-aggregated human IgG); IC (immunocomplexes); PCM (paracoccidioidomycosis);

D O I：

10.1023/A:1013123721376

中图分类号：

学科分类号：

摘要：

Complement receptor type 1 (CR1) is a membrane glycoprotein that acts as a receptor for the C3b, iC3b and C4b fragments of complement. In primates, one function of erythrocytes is to promote safe clearance of immunocomplexes (IC) from the circulation through CR1. Theoretically, in diseases characterized by high levels of circulating IC, an erythrocyte CR1 (CR1/E) deficiency may favor IC deposition in tissues or facilitate inappropriate activation of leukocytes in the circulation. Depression of the cell immune response occurs in paracoccidioidomycosis (PCM), especially in the more severe cases, and is frequently associated with high serum IC levels. In the present study we quantified the number of CR1/E in patients with the acute and chronic forms of PCM before and after treatment and correlated it with serum IC levels and CD4+ and CD8+ T cell concentration in the peripheral blood of these patients. Patients with PCM, particularly those with active disease and who had received treatment for shorter periods of time, had low numbers of CR1/E. In addition, an increase in serum IC concentration and a reduction in the CD4+/CD8+ T cell ratio were observed. After treatment there was a significant increase in mean CR1/E number and a reduction in serum IC levels. In patients with the chronic form of the disease the CD4+/CD8+ T cell ratio tended to increase after treatment and was associated with increased CR1/E levels. These results suggest that the reduction in CR1/E observed in patients is a phenomenon acquired with the disease and that CR1 could play a role in the pathogenesis of PCM.

引用

页码：125 / 133

页数：8

共 47 条

[21]

Maggi E., Giudizi G., Biagiotti R., Annunziato F., Manetti R., Piccinni M.P., Parronchi P., Sampognaro S., Giannarini L., Zuccati G., Romagnani S., Th2-like CD8+ T cells showing B cell helper function and reduced cytolytic activity in human immunodeficiency virus type 1 infection, J Exp Med, 180, pp. 489-495, (1994)

[22]

Coyle A.J., Erard F., Bertrand C., Walti S., Pircher H., Gros L.G., Virus-specific CD8+ cells can switch to interleukin 5 production and induce airway eosinophilia, J Exp Med, 181, pp. 1229-1233, (1995)

[23]

Chequer Bou Habib Oliveira Neto M.P., Ferreira Da Cruz M.F., Galvao-Castro B., The possible role of circulating immune complexes in the deficiency of cell-mediated immunity in paracoccidioidomycosis, Braz J Med Biol Res, 22, pp. 205-212, (1989)

[24]

Feldman G.M., Chuang E.J., Finbloom D.A., IgG immune complexes inhibit IFN-γ induced transcription of the FcgRI gene in human monocytes by preventing the tyrosine phosphorylation of the p91 (Stat I) transcription factor, J Immunol, 154, pp. 318-325, (1995)

[25]

Faist E., Schinkel C., Zimmer S., Update on the mechanisms of immune suppression of injury and immune modulation, World J Surg, 20, pp. 454-459, (1996)

[26]

Beynon H.L., Davies K.A., Haskard D.O., Walport M.J., Erythrocyte complement receptor type 1 and interactions between immune complexes, neutrophils, and endothelium, J Immunol, 153, pp. 3160-3167, (1994)

[27]

Emlen W., Carl V., Burdick G., Mechanism of transfer of immune complexes from red blood cell CR1 to monocytes, Clin Exp Immunol, 89, pp. 8-17, (1992)

[28]

Nielsen C.H., Svehag S.E., Marquart H.V., Leslie R.G., Interactions of opsonized immune complexes with whole blood cells: Binding to erythrocytes restricts complex uptake by leucocyte populations, Scand J Immunol, 40, pp. 228-236, (1994)

[29]

Nielsen C.H., Matthiesen S.H., Lyng I., Leslie R.G., The role of complement receptor type 1 (CR1, CD35) in determining the cellular distribution of opsonized immune complexes between whole blood cells: Kinetic analysis of the buffering capacity of erythrocytes, Immunology, 90, pp. 129-137, (1997)

[30]

Paccaud J.P., Carpentier J.L., Schifferli J.A., Differences in the clustering of complement receptor type 1 (CR1) on polymorphonuclear leukocytes and erythrocytes: Effect on immune adherence, Eur J Immunol, 20, pp. 283-289, (1990)

← 1 2 3 4 5 →