Early metabolism evaluation making traditional Chinese medicine effective and safe therapeutics.

被引：12

作者：

Liu Y. ^{[1
]}

Yang L. ^{[1
]}

机构：

[1] Laboratory of Pharmaceutical Resource Discovery, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian

来源：

Journal of Zhejiang University SCIENCE B | 2006年 / 7卷 / 2期

关键词：

Traditional Chinese medicine (TCM); Metabolism; Gastrointestinal biotransformation;

D O I：

10.1631/jzus.2006.B0099

中图分类号：

学科分类号：

摘要：

Increasing attention is being paid to the scientific evaluation of traditional Chinese medicine (TCM). As many TCMs are capable of biotransformation in the gastrointestinal tract, attention to biotransformation of TCM in the gastrointestinal tract may lead to discovery of the active components and active mechanisms. In this article, we review reports that host metabolic enzymes and intestinal bacteria may be responsible for the metabolism of TCM. Good understanding of the in vivo course of TCM will help us to know how to conduct metabolism evaluation of TCM by using in vitro human-derived system. This evaluation system will create new views on TCM as effective and safe therapeutic agents.

引用

页码：99 / 106

页数：7

共 171 条

[11]

Barone G.W.(1989)The molecular biology of cytochrome P450s Pharmacol. Rev. 40 243-288

[12]

Gurley B.J.(2000)Drug metabolism and pharmacokinetics in drug discovery: a primer for bioanalytical chemists Curr. Sep. 19 17-23

[13]

Ketel B.L.(2004)Proof of the mysterious efficacy of ginseng: basic and clinical trials: metabolic activation of ginsenoside: deglycosylation by intestinal bacteria and esterification with fatty acid J. Pharmacol. Sci. 95 153-157

[14]

Lightfoot M.L.(1996)The nifedipine-rifampin interaction: evidence for induction of gut wall metabolism Drug Metab. Dispos. 24 1121-1123

[15]

Abul-Ezz S.R.(1998)Overview of gut flora and probiotics Int. J. Food Microbiol. 41 85-101

[16]

Chauret N.(2001)Molecular analysis of commensal host-microbial relationships in the intestine (cites personal communication from Joshua Lederberg) Science 291 881-884

[17]

Gauthier A.(2004)Pharmacogenetics of cytochrome P450 and its applications in drug therapy: the past, present and future Trends Pharmacol. Sci. 25 193-200

[18]

Martin J.(1999)Characterization of Phase I and Phase II hepatic drug metabolism activities in a panel of human liver preparations Chemico-Biological Interactions 118 151-169

[19]

Nicoll-Griffith D.A.(2003)The small intestine as a xenobiotic-metabolizing organ Drug Metab. Dispos. 31 1520-1525

[20]

Crespi C.L.(1997)Pharmacokinetics of drug interactions Adv. Pharmacol. 43 189-203

← 1 2 3 4 5 6 7 8 9 10 →