Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders

被引：42

作者：

Blier P. ^{[1
]}

de Montigny C. ^{[1
]}

机构：

[1] Neurobiological Psychiatry Unit, Faculty of Medicine, McGill University, Montreal, QC

来源：

Neuropsychopharmacology | 1999年 / 21卷 / Suppl 1期

关键词：

Antidepressant; Electroconvulsive shocks; Hippocampus; Lithium; Orbito-frontal cortex; Pindolol;

D O I：

10.1016/S0893-133X(99)00036-6

中图分类号：

学科分类号：

摘要：

The therapeutic effectiveness of antidepressant drugs in major depression was discovered by pure serendipity. It took over 20 years before the neurobiological modifications that could mediate the antidepressive response were put into evidence. Indeed, whereas the immediate biochemical effects of these drugs had been well documented, their antidepressant action generally does not become apparent before 2 to 3 weeks of treatment. The different classes of antidepressant treatments were subsequently shown to enhance serotonin neurotransmission albeit via different pre- and postsynaptic mechanisms. Clinical trials based on this hypothesis led to the development of treatment strategies producing greater efficacy and more rapid onset of antidepressant action; that, is lithium addition and pindolol combination, respectively. It is expected that the better understanding recently obtained of the mechanism of action of certain antidepressant drugs in obsessive- compulsive and panic disorders will also lead to more effective treatment strategies for those disorders. © 1999 American College of Neuropsychopharmacology.

引用

页码：91S / 98S

页数：7

共 58 条

[1]

Artigas F., Perez V., Alvarez E., Pindolol induces a rapid improvement of depressed patients with serotonin reuptake inhibitors, Arch Gen Psychiat, 51, pp. 248-251, (1994)

[2]

Baxter L.R., Neuroimaging studies of human anxiety disorders, Psychopharma-Cology: The Fourth Generation of Progress, pp. 1287-1300, (1995)

[3]

Bei'que J.-C., De Montigny C., Blier P., Debonnel G., Blockade of the 5-hydroxytryptamine and norepinephrine uptake by venlafaxine: Comparative study with paroxetine and desipramine, Brit J Pharmacol, 125, pp. 526-532, (1998)

[4]

Bergqvist P., Bouchard C., Blier P., Effect of long-term administration of antidepressant treatments on serotonin release in brain regions involved in obsessive-compulsive disorder, Biolpsychiat, 45, pp. 164-174, (1999)

[5]

Berman R.M., Darnell A.M., Miller H.L., Anand A., Charney D.S., Effect of pindolol in hastening response to fluox-etine in the treatment of major depression: A doubleblind, placebo-controlled trial, Am J Psychiat, 154, pp. 37-43, (1997)

[6]

Blier P., Bergeron R., Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression, J Clinpsychopharmacol, 15, pp. 217-222, (1995)

[7]

Blier P., Bergeron R., Early onset of therapeutic action in depression and greater efficacy of antidepressant treatments: Are they related?, Intclinpsychophar-Macol, 12, pp. 21-28, (1997)

[8]

Blier P., Bouchard C., Modulation of 5-HT release in the guinea pig brain following long-term administration of antidepressant drugs, Br J Pharmacol, 113, pp. 485-495, (1994)

[9]

Blier P., De Montigny C., Electrophysiological studies on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat, J Neurosci, 3, pp. 1270-1278, (1983)

[10]

Blier P., De Montigny C., Serotonergic but not norad-renergic neurons in rat CNS adapt to long-term treatment with monoamine oxidase inhibitors, Neuroscience, 16, pp. 949-955, (1985)

← 1 2 3 4 5 6 →