Serotonin and drug-induced therapeutic responses in major depression, obsessive-compulsive and panic disorders

被引：42

作者：

Blier P. ^{[1
]}

de Montigny C. ^{[1
]}

机构：

[1] Neurobiological Psychiatry Unit, Faculty of Medicine, McGill University, Montreal, QC

来源：

Neuropsychopharmacology | 1999年 / 21卷 / Suppl 1期

关键词：

Antidepressant; Electroconvulsive shocks; Hippocampus; Lithium; Orbito-frontal cortex; Pindolol;

D O I：

10.1016/S0893-133X(99)00036-6

中图分类号：

学科分类号：

摘要：

The therapeutic effectiveness of antidepressant drugs in major depression was discovered by pure serendipity. It took over 20 years before the neurobiological modifications that could mediate the antidepressive response were put into evidence. Indeed, whereas the immediate biochemical effects of these drugs had been well documented, their antidepressant action generally does not become apparent before 2 to 3 weeks of treatment. The different classes of antidepressant treatments were subsequently shown to enhance serotonin neurotransmission albeit via different pre- and postsynaptic mechanisms. Clinical trials based on this hypothesis led to the development of treatment strategies producing greater efficacy and more rapid onset of antidepressant action; that, is lithium addition and pindolol combination, respectively. It is expected that the better understanding recently obtained of the mechanism of action of certain antidepressant drugs in obsessive- compulsive and panic disorders will also lead to more effective treatment strategies for those disorders. © 1999 American College of Neuropsychopharmacology.

引用

页码：91S / 98S

页数：7

共 58 条

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