Lymphatic reprogramming of blood vascular endothelium by Kaposi sarcoma-associated herpesvirus

被引：277

作者：

Hong Y.-K. ^{[1
]}

Foreman K. ^{[2
]}

Shin J.W. ^{[1
]}

Hirakawa S. ^{[1
]}

Curry C.L. ^{[2
]}

Sage D.R. ^{[3
]}

Libermann T. ^{[4
]}

Dezube B.J. ^{[3
]}

Fingeroth J.D. ^{[3
]}

Detmar M. ^{[1
]}

机构：

[1] Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129

[2] Loyola University Medical Center, Maywood

[3] Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston

[4] BIDMC Genomics Center, Department of Medicine, Harvard Medical School, Boston

来源：

Nature Genetics | 2004年 / 36卷 / 7期

关键词：

D O I：

10.1038/ng1383

中图分类号：

学科分类号：

摘要：

Kaposi sarcoma is considered a neoplasm of lymphatic endothelium infected with Kaposi sarcoma-associated herpesvirus. It is characterized by the expression of lymphatic lineage-specific genes by Kaposi sarcoma tumor cells. Here we show that infection of differentiated blood vascular endothelial cells with Kaposi sarcoma-associated herpesvirus leads to their lymphatic reprogramming; induction of ∼70% of the main lymphatic lineage-specific genes, including PROX1, a master regulator of lymphatic development; and downregulation of blood vascular genes.

引用

页码：683 / 685

页数：2