Assessing the Incremental Role of Novel and Emerging Risk Factors

被引：35

作者：

Cook N.R. ^{[1
,2
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机构：

[1] Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02215

[2] Department of Epidemiology, Harvard School of Public Health, Boston, MA

来源：

Current Cardiovascular Risk Reports | 2010年 / 4卷 / 2期

关键词：

Calibration; Discrimination; Model accuracy; Prediction; Risk reclassification;

D O I：

10.1007/s12170-010-0084-x

中图分类号：

学科分类号：

摘要：

Many novel and emerging risk factors exhibit a significant association with cardiovascular disease, but few have been found to improve risk prediction. Statistical criteria used to evaluate such models and markers have largely relied on the receiver operating characteristic curve, which is an insensitive measure of improvement. Recently, new methods have been developed based on risk reclassification or changes in risk strata following use of a new marker or model. Associated measures based on both calibration and discrimination have been proposed. This review describes previous methods used to evaluate models as well as the newly developed methods to evaluate clinical utility. © 2010 Springer Science+Business Media, LLC.

引用

页码：112 / 119

页数：7

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