Circadian analysis of myocardial infarction incidence in an Argentine and Uruguayan population

被引：20

作者：

D'Negri C.E. ^{[1
]}

Nicola-Siri L. ^{[1
,2
,3
]}

Vigo D.E. ^{[1
,4
]}

Girotti L.A. ^{[2
]}

Cardinali D.P. ^{[1
,4
]}

机构：

[1] División de Cardiología, Hospital Ramos Mejía, Buenos Aires

[2] Laboratorio de Bioelectricidad, Escuela de Ingeniería-Bioingeniería, Universidad Nacional de Entre Ríos, Entre Ríos

[3] Departamento de Fisiología, Facultad de Medicina, Universidad de Beunos Aires, 1121 Buenos Aires

来源：

BMC Cardiovascular Disorders | / 6卷 / 1期

关键词：

Myocardial Infarction; Gaussian Component; Free Running; Secondary Minimum; Normal Probability Density Function;

D O I：

10.1186/1471-2261-6-1

中图分类号：

学科分类号：

摘要：

Background: The occurrence of variations in the spectrum of cardiovascular disease between different regions of the world and ethnic groups have been the subject of great interest. This study report the 24-h variation of myocardial infarction (MI) occurrence in patients recruited from CCU located in Argentina and Uruguay. Methods: A cohort of 1063 patients admitted to the CCU within 24 h of the onset of symptoms of an acute MI was examined. MI incidence along the day was computed in 1 h-intervals. Results: A minimal MI incidence between 03:00 and 07:00 h and the occurrence of a first maximum between 08:00 and 12:00 h and a second maximum between 15:00 and 22:00 h were verified. The best fit curve was a 24 h cosinor (acrophase ∼ 19:00 h, accounting for 63 % of variance) together with a symmetrical gaussian bell (maximum at ∼ 10:00 h, accounting for 37 % of variance). A similar picture was observed for MI frequencies among different excluding subgroups (older or younger than 70 years; with or without previous symptoms; diabetics or non diabetics; Q wave- or non-Q wave-type MI; anterior or inferior MI location). Proportion between cosinor and gaussian probabilities was maintained among most subgroups except for older patients who had more MI at the afternoon and patients with previous symptoms who were equally distributed among the morning and afternoon maxima. Conclusions: The results support the existence of two maxima (at morning and afternoon hours) in MI incidence in the Argentine and Uruguayan population. © 2006 D'Negri et al., licensee BioMed Central Ltd.

引用

页数：26

共 41 条

[31] Schaefer B.M., Caracciolo V., Frishman W.H., Charney P., Gender, ethnicity and genetics in cardiovascular disease: Part 1: Basic principles, Heart Dis, 5, pp. 129-143, (2003)
[32] Stergiou G.S., Vemmos K.N., Pliarchopoulou K.M., Synetos A.G., Roussias L.G., Mountokalakis T.D., Parallel morning and evening surge in stroke onset, blood pressure, and physical activity, Stroke, 33, pp. 1480-1486, (2002)
[33] Bursztyn M., Mekler J., Ben Ishay D., The siesta and ambulatory blood pressure: Is waking up the same in the morning and afternoon?, J Hum Hypertens, 10, pp. 287-292, (1996)
[34] Bursztyn M., Ginsberg G., Hammerman-Rozenberg R., Stessman J., The siesta in the elderly: Risk factor for mortality?, Arch Intern Med, 159, pp. 1582-1586, (1999)
[35] Fuster V., Steele P.M., Chesebro J.H., Role of platelets and thrombosis in coronary atherosclerotic disease and sudden death, J Am Coll Cardiol, 5, (1985)
[36] Jovicic A., Mandic S., Circadian variations of platelet aggregability and fibrinolytic activity in healthy subjects, Thromb Res, 62, pp. 65-74, (1991)
[37] Quyyumi A.A., Panza J.A., Diodati J.G., Lakatos E., Epstein S.E., Circadian variation in ischemic threshold. A mechanism underlying the circadian variation in ischemic events, Circulation, 86, pp. 22-28, (1992)
[38] Talan M.I., Engel B.T., Morning increase in whole blood viscosity: A consequence of a homeostatic nocturnal haemodynamic pattern, Acta Physiol Scand, 147, pp. 179-183, (1993)
[39] Feng D.L., Tofler G.H., Diurnal physiologic processes and circadian variation of acute myocardial infarction, J Cardiovasc Risk, 2, pp. 494-498, (1995)
[40] D'Negri C.E., Marelich L., Vigo D.E., Acunzo R.S., Girotti L., Cardinali D.P., Nicola-Siri L., Circadian periodicity of heart rate variability in hospitalized angor patients, Clin Autonom Res, 15, pp. 223-232, (2005)

← 1 2 3 4 5 →