Transformation of interstitial fibroblasts and tubulointerstitial fibrosis in diabetic nephropathy

被引：73

作者：

Ina K. ^{[2
]}

Kitamura H. ^{[2
]}

Tatsukawa S. ^{[2
]}

Takayama T. ^{[2
]}

Fujikura Y. ^{[2
]}

Shimada T. ^{[1
]}

机构：

[1] Department of Health Sciences, School of Nursing, Oita Medical University, Oita

[2] Department of Anatomy, Oita Medical University, Oita 879-5593, 1-1 Idaigaoka, Hasama-machi

来源：

Medical Electron Microscopy | 2002年 / 35卷 / 2期

关键词：

Diabetic nephropathy; Myofibroblast; Transforming growth factor (TGF)-β; Tubulointerstitial fibrosis;

D O I：

10.1007/s007950200011

中图分类号：

学科分类号：

摘要：

The developmental mechanism of tubulointerstitial fibrosis in diabetic nephropathy (DN) has not been elucidated. Tubulointerstitial fibrosis, as well as glomerulosclerosis, occurs in DN. Myofibroblasts which overproduce extracellular matrix are present in the renal interstitium in diabetics, although they are almost never seen in normal kidneys. The myofibroblasts appear to originate from interstitial fibroblasts. In addition, transforming growth factor-β1 (TGF-β1), which can evoke myofibroblast transformation, is detected in interstitial cells in the diabetic kidney, but not in the normal kidney. Taken together, these findings led us to speculate that TGF-β1 induces the transformation of interstitial fibroblasts into myofibroblasts, followed by tubulointerstitial fibrosis. Based on this speculation, we discuss the developmental mechanism of tubulointerstitial fibrosis in this review.

引用

页码：87 / 95

页数：8

共 67 条

[51]

Cruz M.C.I.L., Ruiz-Torres P., Alcami J., Diez-Marques L., Ortega-Velazquez R., Chen S., Rodriguez-Puyol M., Ziyadeh F.N., Rodriguez-Puyol D., Hydrogen peroxide increases extracellular matrix mRNA through TGF-β in human mesangial cells, Kidney Int, 59, pp. 87-95, (2001)

[52]

Ziyadeh F.N., Han D.C., Cohen J.A., Guo J., Cohen M.P., Glycated albumin stimulates fibronectin gene expression in glomerular mesangial cells: Involvement of the transforming growth factor-β system, Kidney Int, 53, pp. 631-638, (1998)

[53]

Chen S., Cohen M.P., Lautenslager G.T., Shearman C.W., Ziyadeh F.N., Glycated albumin stimulates TGF-β1 production and protein kinase C activity in glomerular endothelial cells, Kidney Int, 59, pp. 673-681, (2001)

[54]

Studer R.K., Craven P.A., DeRubertis F.R., Low-density lipoprotein stimulation of mesangial cell fibronectin synthesis: Role of protein kinase C and transforming growth factor-β, J Lab Clin Med, 125, pp. 86-95, (1995)

[55]

Wolf G., Hamann A., Han D.C., Helmchen U., Thaiss F., Ziyadeh F.N., Stahl R.A.K., Leptin stimulates proliferation and TGF-β expression in renal glomerular endothelial cells: Potential role in glomerulosclerosis, Kidney Int, 56, pp. 860-872, (1999)

[56]

Ziyadeh F.N., Snipes E.R., Watanabe M., Alvarez R.J., Goldfarb S., Haverty T.P., High glucose induces cell hypertrophy and stimulates collagen gene transcription in proximal tubule, Am J Physiol, 259, (1990)

[57]

Ziyadeh F.N., Simmons D.A., Snipes E.R., Goldfarb S., Effect of myo-inositol on cell proliferation and collagen transcription and secretion in proximal tubule cells cultured in elevated glucose, J Am Soc Nephrol, 1, pp. 1220-1229, (1991)

[58]

Wolf G., Sharma K., Chen Y., Ericksen M., Ziyadeh F.N., High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β, Kidney Int, 42, pp. 647-656, (1992)

[59]

Ziyadeh F.N., Sharma K., Ericksen M., Wolf G., Stimulation of collagen gene expression and protein synthesis in murine mesangial cells by high glucose is mediated by activation of transforming growth factor-β, J Clin Invest, 93, pp. 536-542, (1994)

[60]

Van Det N.F., Van Den Born J., Tamsa J.T., Verhagen N.A.M., Berden J.H.M., Brujin J.A., Daha M.R., Van Der Woude F.J., Effects of high glucose on the production of heparan sulfate proteoglycan by mesangial and epithelial cells, Kidney Int, 49, pp. 1079-1089, (1996)

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