Prospects of genetic epidemiology in the 21st century

被引：8

作者：

Marieke C.J. Dekker

Cornelia M. van Duijn

机构：

[1] Dept. of Epidemiol. and Biostatist., Erasmus MC, Rotterdam

[2] Dept. of Epidemiol. and Biostatist., Erasmus MC, Rotterdam

来源：

European Journal of Epidemiology | 2003年 / 18卷 / 7期

关键词：

Familial aggregation; Genetic epidemiology; Genetics; Polymorphisms; Study design;

D O I：

10.1023/A:1024933620315

中图分类号：

学科分类号：

摘要：

Genetic epidemiology is a young but rapidly developing discipline. Although its early years were largely dedicated to family-based research in monogenic disorders, now genetic-epidemiologic research increasingly focuses on complex, multifactorial disorders. Along with the development of the human-genome map and advances in molecular technology grows the importance of genetic-epidemiologic applications. Large-scale population-based studies, requiring close integration of genetic and epidemiologic research, determine future research in the field. In this paper, we review the basic principles underlying genetic-epidemiologic research, such as molecular genetics and familial aggregation of disease, as well as the typical study approaches of genome screening and candidate-gene studies.

引用

页码：607 / 616

页数：9

共 38 条

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