Male germ cell death in mouse testes: Possible involvement of Fas and Fas ligand

被引：52

作者：

Koji T. ^{[1
]}

机构：

[1] Department of Histology, Nagasaki Univ. School of Medicine, Nagasaki 852-8523

来源：

Medical Electron Microscopy | 2001年 / 34卷 / 4期

关键词：

Apoptosis; Endocrine-disruptors; Fas/FasL system; Ischemia-reperfusion; Male germ cells; Mouse testis; Spermatogenesis;

D O I：

10.1007/s007950100018

中图分类号：

学科分类号：

摘要：

Loss of germ cells is very common during various stages of mammalian spermatogenesis. Although cell death, particularly apoptosis, has been implicated, our understanding of the mechanisms underlying germ cell death is still limited. In order to elucidate the extent and mechanism of germ cell death, this review first covers what is known of germ cell degeneration in the normal testes of fetal, neonatal, and adult mice from electron microscopy (EM) and from terminal dUTP nick-end labeling (TUNEL) staining. The issue of whether the Fas and Fas ligand (FasL) system is involved in the induction of germ cell apoptosis in normal and damaged testes is then addressed, including consideration of both the ischemia-reperfusion model of testicular torsion and the estrogen-treated testis model of environmental endocrine disruption. Finally, this review proposes that different molecular pathways may be triggered to induce male germ cell apoptosis, depending upon the physiological and pathological states of the germ cells.

引用

页码：213 / 222

页数：9

共 57 条

[1]

De Rooij D.G., Lok D., Regulation of the density of spermatogonia in the seminiferous epithelium of the Chinese hamster. II. Differentiating spermatogonia, Anat Rec, 217, pp. 131-136, (1987)

[2]

Coucouvanis E.C., Sherwood S.W., Carswell-Crumpton C., Spack E.G., Jones P.P., Evidence that the mechanism of prenatal germ cell death in the mouse is apoptosis, Exp Cell Res, 209, pp. 238-247, (1993)

[3]

Packer A.I., Besmer P., Bachvarova R.F., Kit ligand mediates survival of type A spermatogonia and dividing spermatocytes in postnatal mouse testes, Mol Reprod Dev, 42, pp. 303-310, (1995)

[4]

Allan D.J., Harmon B.V., Roberts S.A., Spermatogonial apoptosis has three morphologically recognizable phases and shows no circadian rhythm during normal spermatogenesis in the rat, Cell Prolif, 25, pp. 241-250, (1992)

[5]

Blanco-Rodriguez J., Martinez-Garcia C., Spontaneous germ cell death in the testis of the adult rat takes the form of apoptosis: Re-evaluation of cell types that exhibit the ability to die during spermatogenesis, Cell Prolif, 29, pp. 13-31, (1996)

[6]

Oakberg E.F., A description of spermatogenesis in the mouse and its use in analysis of the cycle of seminiferous epithelium and germ cell renewal, Am J Anat, 99, pp. 391-413, (1956)

[7]

Huckins C., The morphology and kinetics of spermatogonial degeneration in normal adult rats: An analysis using a simplified classification of germinal epithelium, Anat Rec, 190, pp. 905-926, (1978)

[8]

Johnson L., Petty C.S., Neaves W.B., Further quantification of human spermatogenesis: Germ cell loss during postprophase of meiosis and its relationship to daily sperm production, Biol Reprod, 29, pp. 207-215, (1983)

[9]

Roosen-Runge E.C., Leik J., Gonocyte degeneration: In the postnatal male rat, Am J Anat, 122, pp. 275-300, (1968)

[10]

Miething A., Germ-cell death during prespermatogenesis in the testis of the golden hamster, Cell Tissue Res, 267, pp. 583-590, (1992)

← 1 2 3 4 5 6 →