Male germ cell death in mouse testes: Possible involvement of Fas and Fas ligand

被引：52

作者：

Koji T. ^{[1
]}

机构：

[1] Department of Histology, Nagasaki Univ. School of Medicine, Nagasaki 852-8523

来源：

Medical Electron Microscopy | 2001年 / 34卷 / 4期

关键词：

Apoptosis; Endocrine-disruptors; Fas/FasL system; Ischemia-reperfusion; Male germ cells; Mouse testis; Spermatogenesis;

D O I：

10.1007/s007950100018

中图分类号：

学科分类号：

摘要：

Loss of germ cells is very common during various stages of mammalian spermatogenesis. Although cell death, particularly apoptosis, has been implicated, our understanding of the mechanisms underlying germ cell death is still limited. In order to elucidate the extent and mechanism of germ cell death, this review first covers what is known of germ cell degeneration in the normal testes of fetal, neonatal, and adult mice from electron microscopy (EM) and from terminal dUTP nick-end labeling (TUNEL) staining. The issue of whether the Fas and Fas ligand (FasL) system is involved in the induction of germ cell apoptosis in normal and damaged testes is then addressed, including consideration of both the ischemia-reperfusion model of testicular torsion and the estrogen-treated testis model of environmental endocrine disruption. Finally, this review proposes that different molecular pathways may be triggered to induce male germ cell apoptosis, depending upon the physiological and pathological states of the germ cells.

引用

页码：213 / 222

页数：9

共 57 条

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