Hernia repair with porcine small-intestinal submucosa

被引：58

作者：

Ansaloni L. ^{[1
]}

Catena F. ^{[1
]}

Gagliardi S. ^{[1
]}

Gazzotti F. ^{[1
]}

D'Alessandro L. ^{[1
]}

Pinna A.D. ^{[1
]}

机构：

[1] Unit of General, Transplant and Emergency Surgery, St. Orsola-Malpighi University Hospital, 40138 Bologna

来源：

Hernia | 2007年 / 11卷 / 4期

关键词：

Epitope galactosyl-α(1,3)galactose; Extracellular matrix; Hernioplasty; Tissue engineering; Xenograft;

D O I：

10.1007/s10029-007-0225-4

中图分类号：

学科分类号：

摘要：

Purpose: Although at present nonabsorbable meshes are the preferred material for tension-free hernioplasty, some problems with their use have yet to be addressed (i.e., chronic pain and infections). In order to address these disadvantages, a collagen-based material, the porcine small-intestinal submucosa mesh (Surgisis Inguinal Hernia Matrix, Cook Surgical, Bloomington, IN, USA), has recently been developed for hernia repair. Methods: With the aim of investigating the clinical safety and effectiveness of Surgisis IHM inguinal hernia repair, we report our experience of 45 consecutive hernioplasties with a medium-term follow-up. The surgical technique for the use of this material in hernioplasty is described in detail. Results: Although some local (i.e., seromas) and general (i.e., hyperpyrexia), complications appeared in the immediate postoperative period (all of them disappeared spontaneously), no rejection or infection was observed after operations. At the 2-year follow-up, a low degree of pain and discomfort and no recurrences were observed. Conclusions: We conclude that the Surgisis IHM hernioplasty is feasible with promising results and, from a clinical perspective, seems safe and effective. © Springer-Verlag 2007.

引用

页码：321 / 326

页数：5

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[21]

Hodde J.P., Record R.D., Tullius R.S., Badylak S.F., Retention of endothelial cell adherence to porcine-derived extracellular matrix after disinfection and sterilization, Tissue Eng, 8, pp. 225-234, (2002)

[22]

Hodde J., Hiles M., Virus safety of a porcine-derived medical device: Evaluation of a viral inactivation method. Biotechnol, Bioeng, 79, pp. 211-216, (2002)

[23]

Parker D.M., Armstrong P.J., Frizzi J.D., North J.H., Porcine dermal collagen (Permacol) for abdominal wall reconstruction, Curr Surg, 63, pp. 255-258, (2006)

[24]

Ma S.Z., Li X.H., Hu J., Acellular extracellular matrix for inguinal hernia repair, Hernia, 10, pp. 229-231, (2006)

[25]

Buinewicz B., Rosen B., Acellular cadaveric dermis (AlloDerm): A new alternative for abdominal hernia repair, Ann Plast Surg, 52, pp. 188-194, (2004)

[26]

Hodde J., Record R., Tullius R., Badylak S., Fibronectin peptides mediate HMEC adhesion to porcine-derived extracellular matrix, Biomaterials, 23, pp. 1841-1848, (2002)

[27]

Voytik-Harbin S.L., Brightman A.O., Kraine M.R., Waisner B., Badylak S.F., Identification of extractable growth factors from small intestinal submucosa, J Cell Biochem, 67, pp. 478-491, (1997)

[28]

Hodde J.P., Record R.D., Liang H.A., Badylak S.F., Vascular endothelial growth factor in porcine derived extracellular matrix, Endothelium, 8, pp. 11-24, (2001)

[29]

Raeder R.H., Badylak S.F., Sheehan C., Kallakury B., Metzger D.W., Natural anti-galactose alpha1,3 galactose antibodies delay, but do not prevent the acceptance of extracellular matrix xenografts, Transpl Immunol, 10, pp. 15-24, (2002)

[30]

Allman A.J., McPherson T.B., Badylak S.F., Merrill L.C., Kallakury B., Sheehan C., Raeder R.H., Metzger D.W., Xenogeneic extracellular matrix grafts elicit a TH2-restricted immune response, Transplantation, 71, pp. 1631-1640, (2001)

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