Epithelial antimicrobial peptides in host defense against infection

被引：357

作者：

Bals R. ^{[1
]}

机构：

[1] Ludwig-Maximilians-Universität, Munich

来源：

Respiratory Research | / 1卷 / 3期

关键词：

cathelicidin; chronic bronchitis; defensin; host defense; infection;

D O I：

10.1186/rr25

中图分类号：

学科分类号：

摘要：

One component of host defense at mucosal surfaces seems to be epithelium-derived antimicrobial peptides. Antimicrobial peptides are classified on the basis of their structure and amino acid motifs. Peptides of the defensin, cathelicidin, and histatin classes are found in humans. In the airways, α-defensins and the cathelicidin LL-37/hCAP-18 originate from neutrophils. β-Defensins and LL-37/hCAP-18 are produced by the respiratory epithelium and the alveolar macrophage and secreted into the airway surface fluid. Beside their direct antimicrobial function, antimicrobial peptides have multiple roles as mediators of inflammation with effects on epithelial and inflammatory cells, influencing such diverse processes as proliferation, immune induction, wound healing, cytokine release, chemotaxis, protease-antiprotease balance, and redox homeostasis. Further, antimicrobial peptides qualify as prototypes of innovative drugs that might be used as antibiotics, anti-lipopolysaccharide drugs, or modifiers of inflammation. © 2000 Current Science Ltd.

引用

共 64 条

[11] Quayle, A.J., Porter, E.M., Nussbaum, A.A., Wang, Y.M., Brabec, C., Yip, K.P., Mok, S.C., Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract. (1998) Am J Pathol, 152, pp. 1247-1258
[12] Linzmeier, R., Ho, C.H., Hoang, B.V., Ganz, T., A 450-kb contig of defensin genes on human chromosome 8p23. (1999) Gene, 233, pp. 205-211. , 10375637
[13] Wilson, C.L., Ouellette, A.J., Satchell, D.P., Ayabe, T., Lopez-Boado, Y.S., Stratman, J.L., Hultgren, S.J., Parks, W.C., Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense. (1999) Science, 286, pp. 113-117. , 10506557
[14] Soong, L., Ganz, T., Ellison, A., Caughey, G., Purification and characterization of defensins from cystic fibrosis sputum. (1997) Inflamm Res, 46, pp. 98-102. , 9098722
[15] Diamond, G., Zasloff, M., Eck, H., Brasseur, M., Maloy, W.L., Bevins, C.L., Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA. (1991) Proc Natl Acad Sci USA, 88, pp. 3952-3956. , 51571, 2023943
[16] Bensch, K., Raida, M., Magert, H.-J., Schulz-Knappe, P., Forssmann, W.-G., HBD-1: a novel β-defensin from human plasma. (1995) FEBS Lett, 368, pp. 331-335. , 7628632
[17] McCray, P., Bentley, L., Human airway epithelia express a β-defensin. (1997) Am JRespir Cell Mol Biol, 16, pp. 343-349
[18] Goldman, M.J., Anderson, G.M., Stolzenberg, E.D., Kari, U.P., Zasloff, M., Wilson, J.M., Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. (1997) Cell, 88, pp. 553-560
[19] Valore, E.V., Park, C.H., Quayle, A.J., Wiles, K.R., McCray, P.B., Ganz, T., Human β-defensin-1: an antimicrobial peptide of urogenital tissues. (1998) J Clin Invest, 101, pp. 1633-1642
[20] Harder, J., Bartels, J., Christophers, E., Schroeder, J.-M., A peptide antibiotic from human skin. (1997) Nature, 387, p. 861. , 9202117

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