Comorbid depression in rheumatoid arthritis: Pathophysiology and clinical implications

被引：107

作者：

Bruce T.O. ^{[1
]}

机构：

[1] Department of Neuropsychiatry and Behavioral Sciences, University of South Carolina School of Medicine, Columbia, SC 29203

来源：

Current Psychiatry Reports | 2008年 / 10卷 / 3期

关键词：

Rheumatoid Arthritis; Depressive Symptom; Suicidal Ideation; Rheumatol; Illness Perception;

D O I：

10.1007/s11920-008-0042-1

中图分类号：

学科分类号：

摘要：

Rheumatoid arthritis (RA) is a chronic inflammatory illness that primarily affects the joints. It is associated with symptoms of fatigue, pain, and sleep disturbances that can overlap with or mimic symptoms of depression. Depressive symptoms are highly comorbid, with RA and may occur with at least mild severity in up to 42% of RA patients. RA and depression contribute to mortality, decreased quality of life, increased health care costs, and disability. Inflammatory pathways may hold the key to a link between depression and RA, and cytokines have been a major target of research in this area. This arficie reviews some of the most recent research and commentary on this complex relationship. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：258 / 264

页数：6

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