Effects of deletion of the prolactin receptor on ovarian gene expression

被引：98

作者：

Isabelle Grosdemouge

Anne Bachelot

Aurélie Lucas

Nathalie Baran

Paul A Kelly

Nadine Binart

机构：

[1] Dept. of Molecular Endocrinology, INSERM U344, Fac. de Med. Necker-Enfants Malades

来源：

Reproductive Biology and Endocrinology | / 1卷 / 1期

关键词：

Fertility; Mice; Ovary; Physiology; Prolactin receptor;

D O I：

10.1186/1477-7827-1-12

中图分类号：

学科分类号：

摘要：

Prolactin (PRL) exerts pleiotropic physiological effects in various cells and tissues, and is mainly considered as a regulator of reproduction and cell growth. Null mutation of the PRL receptor (R) gene leads to female sterility due to a complete failure of embryo implantation. Pre-implantatory egg development, implantation and decidualization in the mouse appear to be dependent on ovarian rather than uterine PRLR expression, since progesterone replacement permits the rescue of normal implantation and early pregnancy. To better understand PRL receptor deficiency, we analyzed in detail ovarian and corpora lutea development of PRLR-/- females. The present study demonstrates that the ovulation rate is not different between PRLR+/+ and PRLR-/-mice. The corpus luteum is formed but an elevated level of apoptosis and extensive inhibition of angiogenesis occur during the luteal transition in the absence of prolactin signaling. These modifications lead to the decrease of LH receptor expression and consequently to a loss of the enzymatic cascades necessary to produce adequate levels of progesterone which are required for the maintenance of pregnancy. © 2003 Grosdemouge et al; licensee BioMed Central Ltd.

引用

页数：16

共 40 条

[1] Bole-Feysot C., Goffin V., Edery M., Binart N., Kelly P.A., Prolactin and its receptor: Actions, signal transduction pathways and phenotypes observed in prolactin receptor knockout mice, Endocr. Rev., 19, pp. 225-268, (1998)
[2] Gibori G., The corpus luteum of pregnancy, The Ovary, pp. 261-317, (1992)
[3] Armstrong D.T., Knudsen K.A., Miller L.S., Effects of prolactin upon cholesterol metabolism and progesterone biosynthesis in corpora lutea of rats hypophysectomized during pseudopregnancy, Endocrinology, 86, pp. 634-641, (1970)
[4] Ota H., Wakizaka A., Fukushima M., Maki M., Dual regulation of rat ovarian LH-receptor by the administration of prolactin or sulpiride, IRCS Med. Sci., 63, pp. 257-264, (1985)
[5] Berhman H.R., Orczyk G.P., MacDonald G.J., Greep R.O., Prolactin induction of enzymes controlling luteal cholesterol ester turnover, Endocrinology, 87, pp. 1251-1256, (1970)
[6] Ormandy C.J., Camus A., Barra J., Damotte D., Lucas B.K., Buteau H., Edery M., Brousse N., Babinet C., Binart N., Kelly P.A., Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse, Genes Dev., 11, pp. 167-178, (1997)
[7] Clarke D.L., Linzer D.H., Changes in prolactin receptor expression during pregnancy in the mouse ovary, Endocrinology, 133, pp. 224-232, (1993)
[8] Gunnet J.W., Freeman M.E., The mating-induced release of prolactin: A unique neuroendocrine response, Endocr. Rev., 4, pp. 44-61, (1983)
[9] Gunnet J.W., Freeman M.E., Hypothalamic regulation of mating-induced prolactin release. Effect of electrical stimulation of the medial preoptic area in conscious female rats, Neuroendocrinology, 38, pp. 12-16, (1984)
[10] Binart N., Helloco C., Ormandy C.J., Barra J., Clement-Lacroix P., Baran N., Kelly P.A., Rescue of preimplantatory egg development and embryo implantation in prolactin receptor-deficient mice after progesterone administration, Endocrinology, 141, pp. 2691-2697, (2000)

← 1 2 3 4 →