Effects of deletion of the prolactin receptor on ovarian gene expression

被引：98

作者：

Isabelle Grosdemouge

Anne Bachelot

Aurélie Lucas

Nathalie Baran

Paul A Kelly

Nadine Binart

机构：

[1] Dept. of Molecular Endocrinology, INSERM U344, Fac. de Med. Necker-Enfants Malades

来源：

Reproductive Biology and Endocrinology | / 1卷 / 1期

关键词：

Fertility; Mice; Ovary; Physiology; Prolactin receptor;

D O I：

10.1186/1477-7827-1-12

中图分类号：

学科分类号：

摘要：

Prolactin (PRL) exerts pleiotropic physiological effects in various cells and tissues, and is mainly considered as a regulator of reproduction and cell growth. Null mutation of the PRL receptor (R) gene leads to female sterility due to a complete failure of embryo implantation. Pre-implantatory egg development, implantation and decidualization in the mouse appear to be dependent on ovarian rather than uterine PRLR expression, since progesterone replacement permits the rescue of normal implantation and early pregnancy. To better understand PRL receptor deficiency, we analyzed in detail ovarian and corpora lutea development of PRLR-/- females. The present study demonstrates that the ovulation rate is not different between PRLR+/+ and PRLR-/-mice. The corpus luteum is formed but an elevated level of apoptosis and extensive inhibition of angiogenesis occur during the luteal transition in the absence of prolactin signaling. These modifications lead to the decrease of LH receptor expression and consequently to a loss of the enzymatic cascades necessary to produce adequate levels of progesterone which are required for the maintenance of pregnancy. © 2003 Grosdemouge et al; licensee BioMed Central Ltd.

引用

页数：16

共 40 条

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