ASK family proteins in stress response and disease

被引:51
作者
Fujisawa, Takao
Takeda, Kohsuke
Ichijo, Hidenori
机构
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Cell Signaling, Bunkyo Ku, Tokyo 1130033, Japan
[2] CREST, Japan Sci & Technol Crop, COE Program, Bunkyo Ku, Tokyo 1130033, Japan
关键词
ASK1; ASK2; JNK; lipopolysaccharide (LPS); MAP kinase (MAPK); oxidative stress; p38; reactive oxygen species (ROS); SIGNAL-REGULATING KINASE-1; CELL-DEATH; CARDIAC-HYPERTROPHY; OXIDATIVE STRESS; CUTTING EDGE; APOPTOSIS; ACTIVATION; PATHWAYS; THIOREDOXIN; LIPOPOLYSACCHARIDE;
D O I
10.1007/s12033-007-0053-x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Cells are continuously exposed to reactive oxygen species (ROS) generated by aerobic metabolism. Excessively generated ROS causes severe dysfunctions to cells as oxidative stress. On the other hand, there is increasing evidence that ROS plays important roles as a signaling intermediate that induces a wide variety of cellular responses such as proliferation, differentiation, senescence, and apoptosis. To transmit physiological ROS-mediated signals and to adapt to oxidative stress, cells are equipped with various intracellular signal transduction systems, represented by mitogen-activated protein kinase (MAPK) cascades. Apoptosis signal-regulating kinase I (ASK1) is an upstream regulator of the stress-activated MAPK cascades and has been shown to play critical roles in ROS-mediated cellular responses. Here, we highlight the roles of members of the ASK family, which consists of ASK1 and newly characterized ASK2, in ROS signaling with their possible involvement in human diseases.
引用
收藏
页码:13 / 18
页数:6
相关论文
共 26 条
[1]   Toll-like receptor signalling [J].
Akira, S ;
Takeda, K .
NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :499-511
[2]   The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology [J].
Bedard, Karen ;
Krause, Karl-Heinz .
PHYSIOLOGICAL REVIEWS, 2007, 87 (01) :245-313
[3]   Myocardial ischemia and reperfusion injury [J].
Buja, LM .
CARDIOVASCULAR PATHOLOGY, 2005, 14 (04) :170-175
[4]   Cutting edge: Apoptosis-regulating signal kinase 1 is required for reactive oxygen species-mediated activation of IFN regulatory factor 3 by. lipopolysaccharide [J].
Chiang, Edward ;
Dang, Oanh ;
Anderson, Keith ;
Matsuzawa, Atsushi ;
Ichijo, Hidenori ;
David, Michael .
JOURNAL OF IMMUNOLOGY, 2006, 176 (10) :5720-5724
[5]   Thioredoxin and protein kinases in redox signaling [J].
Fujino, Go ;
Noguchi, Takuya ;
Takeda, Kohsuke ;
Ichijo, Hidenori .
SEMINARS IN CANCER BIOLOGY, 2006, 16 (06) :427-435
[6]   The ASK1-MAP kinase pathways in immune and stress responses [J].
Hayakawa, Teruyuki ;
Matsuzawa, Atsushi ;
Noguchi, Takuya ;
Takeda, Kohsuke ;
Ichijo, Hidenori .
MICROBES AND INFECTION, 2006, 8 (04) :1098-1107
[7]   Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways [J].
Ichijo, H ;
Nishida, E ;
Irie, K ;
tenDijke, P ;
Saitoh, M ;
Moriguchi, T ;
Takagi, M ;
Matsumoto, K ;
Miyazono, K ;
Gotoh, Y .
SCIENCE, 1997, 275 (5296) :90-94
[8]   Apoptosis signal-regulating kinase 1 plays a pivotal role in angiotensin II - Induced cardiac hypertrophy and remodeling [J].
Izumiya, Y ;
Kim, S ;
Izumi, Y ;
Yoshida, K ;
Yoshiyama, M ;
Matsuzawa, A ;
Ichijo, H ;
Iwao, H .
CIRCULATION RESEARCH, 2003, 93 (09) :874-883
[9]   Amyloid β induces neuronal cell death through ROS-mediated ASK1 activation [J].
Kadowaki, H ;
Nishitoh, H ;
Urano, F ;
Sadamitsu, C ;
Matsuzawa, A ;
Takeda, K ;
Masutani, H ;
Yodoi, J ;
Urano, Y ;
Nagano, T ;
Ichijo, H .
CELL DEATH AND DIFFERENTIATION, 2005, 12 (01) :19-24
[10]   Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation [J].
Kyriakis, JM ;
Avruch, J .
PHYSIOLOGICAL REVIEWS, 2001, 81 (02) :807-869