Hydrogen peroxide: A metabolic by-product or a common mediator of ageing signals?

被引：6

作者：

Giorgio M. ^{[1
]}

Trinei M. ^{[2
]}

Migliaccio E. ^{[1
]}

Pelicci P.G. ^{[1
]}

机构：

[1] Department of Experimental Oncology, IEO-European Institute of Oncology, IFOM-FIRC Institute of Molecular Oncology

[2] Congenia Srl

来源：

Nature Reviews Molecular Cell Biology | 2007年 / 8卷 / 9期

关键词：

D O I：

10.1038/nrm2240

中图分类号：

学科分类号：

摘要：

The reactive oxygen species that are generated by mitochondrial respiration, including hydrogen peroxide (H2O2), are potent inducers of oxidative damage and mediators of ageing. It is not clear, however, whether oxidative stress is the result of a genetic programme or the by-product of physiological processes. Recent findings demonstrate that a fraction of mitochondrial H2O2, produced by a specialized enzyme as a signalling molecule in the pathway of apoptosis, induces intracellular oxidative stress and accelerates ageing. We propose that genes that control H2O2 production are selected determinants of lifespan. © 2007 Nature Publishing Group.

引用

页码：722 / 728

页数：6

共 80 条

[1]

Frisard M., Ravussin E., Energy metabolism and oxidative stress: Impact on the metabolic syndrome and the ageing process, Endocrine, 29, pp. 27-32, (2006)

[2]

Harman D., Ageing: Phenomena and theories, Ann. NY Acad. Sci, 854, pp. 1-7, (1998)

[3]

Balaban R.S., Nemoto S., Finkel T., Mitochondria, oxidants, and ageing, Cell, 120, pp. 483-495, (2005)

[4]

Chance B., Sies H., Boveris A., Hydroperoxide metabolism in mammalian organs, Physiol Rev, 59, pp. 527-605, (1979)

[5]

Bayne A.C., Mockett R.J., Orr W.C., Sohal R.S., Enhanced catabolism of mitochondrial superoxide/ hydrogen peroxide and ageing in transgenic Drosophila, Biochem. J, 391, pp. 277-284, (2005)

[6]

Valko M., Et al., Free radicals and antioxidants in normal physiological functions and human disease, Int. J. Biochem. Cell Biol, 39, pp. 44-84, (2007)

[7]

Gius D., Spitz D.R., Redox signaling in cancer biology, Antioxid. Redox Signal, 8, pp. 1249-1252, (2006)

[8]

Stone J.R., Yang S., Hydrogen peroxide: A signaling messenger, Antioxid. Redox Signal, 8, pp. 243-270, (2006)

[9]

Choi H., Et al., Structural basis of the redox switch in the OxyR transcription factor, Cell, 105, pp. 103-113, (2001)

[10]

Vivancos A.P., Castillo E.A., Jones N., Ayte J., Hidalgo E., Activation of the redox sensor Pap1 by hydrogen peroxide requires modulation of the intracellular oxidant concentration, Mol. Microbiol, 52, pp. 1427-1435, (2004)

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